8PFQ
 
 | | RNA structure with 1-methylpseudoridine, P1 space group | | Descriptor: | Chains: A,B, MAGNESIUM ION | | Authors: | Spingler, B, McAuley, K, Nievergelt, P, Thorn, A. | | Deposit date: | 2023-06-16 | | Release date: | 2024-01-31 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.01 Å) | | Cite: | RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.
Chemmedchem, 19, 2024
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6Y9H
 | | Thrombin in complex with D-Phe-Pro-m-Trifluoromethylbenzylamide derivative (phe2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-Phe-Pro-m-Trifluoromethylbenzylamide derivative (phe2), DIMETHYL SULFOXIDE, ... | | Authors: | Sandner, A, Heine, A, Klebe, G, Abazi, N. | | Deposit date: | 2020-03-09 | | Release date: | 2021-03-31 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Thrombin in complex with D-Phe-Pro-m-Trifluoromethylbenzylamide derivative (phe2)
To be published
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8PM4
 | | Cryo-EM structure of the Cas12m-crRNA-target DNA complex | | Descriptor: | DNA oligoduplex, non-target strand, chain D, ... | | Authors: | Sasnauskas, G, Tamulaitiene, G, Karvelis, T, Bigelyte, G, Siksnys, V. | | Deposit date: | 2023-06-28 | | Release date: | 2024-02-07 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.
Nucleic Acids Res., 52, 2024
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4XAK
 | | Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy chain of neutralizing antibody m336, ... | | Authors: | Zhou, T, Dimtrov, D.S, Ying, T. | | Deposit date: | 2014-12-15 | | Release date: | 2015-08-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.
Nat Commun, 6, 2015
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4XBM
 | | X-ray crystal structure of Notch ligand Delta-like 1 | | Descriptor: | Delta-like protein 1, alpha-L-fucopyranose | | Authors: | Kershaw, N.J, Burgess, A.W, Church, N.L, Luo, C.S, Adam, T.E. | | Deposit date: | 2014-12-17 | | Release date: | 2015-03-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Notch ligand delta-like1: X-ray crystal structure and binding affinity.
Biochem.J., 468, 2015
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7QEZ
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6YB6
 | | Thrombin in complex with D-Phe-Pro-3-chloro-1,3-dihydroxybenzylamide derivative (13c) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-Phe-Pro-3-chloro-1,3-dihydroxybenzylamide derivative, DIMETHYL SULFOXIDE, ... | | Authors: | Sandner, A, Heine, A, Klebe, G, Abazi, N. | | Deposit date: | 2020-03-16 | | Release date: | 2021-03-31 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Thrombin in complex with D-Phe-Pro-3-chloro-1,3-dihydroxybenzylamide derivative (13c)
To be published
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8Q5Q
 | | d(ATTTC)3 dimeric structure | | Descriptor: | DNA (5'-D(*AP*TP*TP*TP*(DNR)P*AP*TP*TP*TP*CP*AP*TP*TP*TP*C)-3') | | Authors: | Trajkovski, M, Pastore, A, Plavec, J. | | Deposit date: | 2023-08-09 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-06 | | Method: | SOLUTION NMR | | Cite: | Dimeric structures of DNA ATTTC repeats promoted by divalent cations.
Nucleic Acids Res., 52, 2024
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8PPM
 | | IL-12Rb1 neutralizing Fab4, crystal kappa variant | | Descriptor: | Fab4 Light chain, crystal kappa variant, Fab4 heavy chain, ... | | Authors: | Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-07-07 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8Q72
 | | E. coli plasmid-borne JetABCD(E248A) core in a cleavage-competent state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Circular plasmid DNA (1840-MER), JetA, ... | | Authors: | Roisne-Hamelin, F, Li, Y, Gruber, S. | | Deposit date: | 2023-08-15 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Structural basis for plasmid restriction by SMC JET nuclease.
Mol.Cell, 84, 2024
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8PM0
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8Q3K
 | | The open state of the ASFV apo-RNA polymerase | | Descriptor: | DNA-directed RNA polymerase RPB1 homolog, DNA-directed RNA polymerase RPB10 homolog, DNA-directed RNA polymerase RPB2 homolog, ... | | Authors: | Pilotto, S, Sykora, M, Cackett, G, Werner, F. | | Deposit date: | 2023-08-04 | | Release date: | 2024-02-14 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Structure of the recombinant RNA polymerase from African Swine Fever Virus.
Nat Commun, 15, 2024
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4XBL
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8QA9
 | | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA | | Descriptor: | DNA (5'-D(*TP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*A)-3'), SULFATE ION, Transcriptional repressor protein KorB, ... | | Authors: | McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. | | Deposit date: | 2023-08-22 | | Release date: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA
To Be Published
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8PKI
 | | Cryo-EM structure of NR5A2-nucleosome complex SHL+5.5 | | Descriptor: | DNA, Histone H2A, Histone H2B type 1-C/E/G, ... | | Authors: | Kobayashi, W, Sappler, A, Bollschweiler, D, Kummecke, M, Basquin, J, Arslantas, E, Ruangroengkulrith, S, Hornberger, R, Duderstadt, K, Tachibana, K. | | Deposit date: | 2023-06-26 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.
Nat.Struct.Mol.Biol., 31, 2024
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1BQH
 | | MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (BETA-2-MICROGLOBULIN ), PROTEIN (CD8A OR LYT2 OR LYT-2), ... | | Authors: | Wang, J.H, Reinherz, E.L, Kern, P.S, Chang, H.C. | | Deposit date: | 1998-08-16 | | Release date: | 1998-08-19 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.
Immunity, 9, 1998
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8PKJ
 | | Cryo-EM structure of the nucleosome containing Nr5a2 motif at SHL+5.5 | | Descriptor: | DNA, Histone H2A, Histone H2B, ... | | Authors: | Kobayashi, W, Sappler, A, Bollschweiler, D, Kummecke, M, Basquin, J, Arslantas, E, Ruangroengkulrith, S, Hornberger, R, Duderstadt, K, Tachibana, K. | | Deposit date: | 2023-06-26 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.
Nat.Struct.Mol.Biol., 31, 2024
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8Q4O
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7B0B
 | | Fab HbnC3t1p1_C6 bound to SARS-CoV-2 RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, IGK@ protein, ... | | Authors: | Borenstein-Katz, A, Diskin, R. | | Deposit date: | 2020-11-19 | | Release date: | 2021-12-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.
Immunity, 56, 2023
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8Q3E
 | | High Resolution Structure of Nucleosome Core with Bound Foamy Virus GAG Peptide | | Descriptor: | DNA (145-MER), GLY-GLY-TYR-ASN-LEU-ARG-PRO-ARG-THR-TYR-GLN-PRO-GLN-ARG-TYR-GLY-GLY-GLY, Histone H2A type 1-B/E, ... | | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | | Deposit date: | 2023-08-04 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.174 Å) | | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin.
Rsc Adv, 14, 2024
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6SOZ
 | | Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, ... | | Authors: | Trevor, C, Carrington, M, Higgins, M.K. | | Deposit date: | 2019-08-30 | | Release date: | 2019-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
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4XOP
 | | Tailspike protein double mutant D339N/E372Q of E. coli bacteriophage HK620 in complex with hexasaccharide | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, SODIUM ION, ... | | Authors: | Gohlke, U, Broeker, N.K, Heinemann, U, Seckler, R, Barbirz, S. | | Deposit date: | 2015-01-16 | | Release date: | 2016-01-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Enthalpic cost of water removal from a hydrophobic glucose binding cavity on HK620 tailspike protein.
to be published
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8POK
 | | Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HISTAMINE, ... | | Authors: | Schnelle, K, Koeck, Z, Persechino, M, Umbach, S, Schihada, H, Januliene, D, Parey, K, Pockes, S, Kolb, P, Doetsch, V, Moeller, A, Hilger, D, Bernhard, F. | | Deposit date: | 2023-07-05 | | Release date: | 2024-03-06 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment.
Nat Commun, 15, 2024
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8PYR
 | | Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex | | Descriptor: | 1,2-ETHANEDIOL, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | | Authors: | Anand, K, Duster, R, Geyer, M. | | Deposit date: | 2023-07-26 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis of Cdk7 activation by dual T-loop phosphorylation.
Biorxiv, 2024
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8Q3M
 | | Structure of Nucleosome Core with a Bound Kaposi Sarcoma Associated Herpesvirus LANA Peptide Having a Methionine to Ornithine Substitution | | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | | Deposit date: | 2023-08-04 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.503 Å) | | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin.
Rsc Adv, 14, 2024
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