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2R3I	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3M	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: Cell division protein kinase 2, N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3Q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
6GSA	Core Centromere Binding Factor 3 (CBF3) with monomeric Ndc10 Descriptor: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... Authors: Zhang, W.J, Lukoynova, N, Vaughan, C.K. Deposit date: 2018-06-13 Release date: 2018-08-01 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10. Cell Rep, 24, 2018
2R3H	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3J	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
8BYL	Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex Descriptor: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ... Authors: Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M. Deposit date: 2022-12-13 Release date: 2023-06-28 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
7T1Y	Structure of the Fbw7-Skp1-MycCdegron complex Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ... Authors: Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. Deposit date: 2021-12-02 Release date: 2022-02-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8, 2022
6WNX	FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide Descriptor: Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ... Authors: Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC) Deposit date: 2020-04-23 Release date: 2020-05-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide To Be Published
5V4B	Crystal structure of the Skp1-FBXW7-DISC1 complex Descriptor: DISC1 peptide, F-box/WD repeat-containing protein 7, IMIDAZOLE, ... Authors: Li, Y, Baillie, G.S, Hao, B. Deposit date: 2017-03-08 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Mol. Psychiatry, 23, 2018
6HG4	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-22 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
6HG9	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-23 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.62 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
6FE8	Cryo-EM structure of the core Centromere Binding Factor 3 complex Descriptor: Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 Authors: Zhang, W.J, Lukoynova, N, Miah, S, Vaughan, C.K. Deposit date: 2017-12-30 Release date: 2018-08-01 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10. Cell Rep, 24, 2018
5IBK	Skp1-F-box in complex with a ubiquitin variant Descriptor: F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 Authors: Orlicky, S, Sicheri, F. Deposit date: 2016-02-22 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.503 Å) Cite: Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113, 2016
5K35	Structure of the Legionella effector, AnkB, in complex with human Skp1 Descriptor: Ankyrin-repeat protein B, S-phase kinase-associated protein 1 Authors: Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) Deposit date: 2016-05-19 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System. Structure, 25, 2017
6H5H	A computationally designed dRP lyase domain reconstructed from two heterologous fragments Descriptor: polb4 Authors: ElGamacy, M, Coles, M, Lupas, A.N. Deposit date: 2018-07-24 Release date: 2018-12-12 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Asymmetric protein design from conserved supersecondary structures. J. Struct. Biol., 204, 2018
6C16	Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex. Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1 Authors: Manczyk, N, Sicheri, F. Deposit date: 2018-01-04 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.27 Å) Cite: A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure, 26, 2018
6BVA	Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex. Descriptor: Lysine-specific demethylase 2B, Polyubiquitin-B, S-phase kinase-associated protein 1 Authors: Manczyk, N, Sicheri, F. Deposit date: 2017-12-12 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.66 Å) Cite: A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure, 26, 2018
6BYH	Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex. Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1 Authors: Manczyk, N, Sicheri, F. Deposit date: 2017-12-20 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.61 Å) Cite: A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure, 26, 2018
2ASS	Crystal structure of the Skp1-Skp2-Cks1 complex Descriptor: BENZAMIDINE, Cyclin-dependent kinases regulatory subunit 1, PHOSPHATE ION, ... Authors: Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P. Deposit date: 2005-08-24 Release date: 2005-10-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20, 2005
2R3P	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2E32	Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A Authors: Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K. Deposit date: 2006-11-20 Release date: 2007-03-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.52 Å) Cite: Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase Proc.Natl.Acad.Sci.Usa, 104, 2007
2R3G	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2E31	Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A Authors: Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K. Deposit date: 2006-11-20 Release date: 2007-03-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase Proc.Natl.Acad.Sci.Usa, 104, 2007
2R3R	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2021-07-28 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008

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