5V4B

Crystal structure of the Skp1-FBXW7-DISC1 complex

Summary for 5V4B

• Entry DOI: 10.2210/pdb5v4b/pdb
• Related: 2OVP 2OVQ 2OVR
• Descriptor: S-phase kinase-associated protein 1,S-phase kinase-associated protein 1, F-box/WD repeat-containing protein 7, DISC1 peptide, ... (6 entities in total)
• Functional Keywords: ubiquitin ligase/psychiatric disorders, transcription-cell c complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Nucleus, nucleoplasm . Isoform 2: Cytoplasm . Isoform 3: Nucleus, nucleolus : Q969H0
• Total number of polymer chains: 3
• Total formula weight: 69606.64

Authors

Li, Y.,Baillie, G.S.,Hao, B. (deposition date: 2017-03-08, release date: 2017-09-20, Last modification date: 2023-10-04)

• Primary citation: Yalla, K.,Elliott, C.,Day, J.P.,Findlay, J.,Barratt, S.,Hughes, Z.A.,Wilson, L.,Whiteley, E.,Popiolek, M.,Li, Y.,Dunlop, J.,Killick, R.,Adams, D.R.,Brandon, N.J.,Houslay, M.D.,Hao, B.,Baillie, G.S.; FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.; Mol. Psychiatry, 23:1278-1286, 2018; PubMed: 28727686; DOI: 10.1038/mp.2017.138

Experimental method

X-RAY DIFFRACTION (2.6 Å)