5V4B

Crystal structure of the Skp1-FBXW7-DISC1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	S-phase kinase-associated protein 1,S-phase kinase-associated protein 1	polymer	149	16841.2	1	UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB	Homo sapiens (Human)	Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1
2	B	F-box/WD repeat-containing protein 7	polymer	444	50150.2	1	UniProt (Q969H0) Pfam (PF00400) Pfam (PF12937) In PDB	Homo sapiens (Human)	Archipelago homolog,hAgo,F-box and WD-40 domain-containing protein 7,F-box protein FBX30,SEL-10,hCdc4
3	C	DISC1 peptide	polymer	15	1681.6	1	UniProt (by SIFTS) (Q9NRI5) In PDB	Homo sapiens
4	B	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
5	B	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
6		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A: 1001 - 1069 (UniProt: P63208)

PDB	External Database	Details
Ala 1002	Pro 2	engineered mutation
-	Asp 37	deletion
-	Asp 38	deletion
-	Glu 39	deletion
-	Gly 40	deletion
-	Asp 41	deletion
-	Asp 42	deletion

A: 1082 - 1163 (UniProt: P63208)

PDB	External Database	Details
Gly 1070	-	linker
Gly 1071	-	linker
Ser 1072	-	linker
Gly 1073	-	linker
Ala 1129	Gly 129	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	68673.0
Non-Polymers*	Number of molecules	10
	Total formula weight	933.7
All*	Total formula weight	69606.6

*Water molecules are not included.