2OVQ
Structure of the Skp1-Fbw7-CyclinEdegC complex
Summary for 2OVQ
Entry DOI | 10.2210/pdb2ovq/pdb |
Related | 2OVP 2OVR |
Descriptor | S-phase kinase-associated protein 1A, F-box/WD repeat protein 7, cyclinE C-terminal degron, ... (5 entities in total) |
Functional Keywords | f-box; wd40 domains; double phosphorylation, transcription-cell cycle complex, transcription/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus, nucleoplasm . Isoform 2: Cytoplasm . Isoform 3: Nucleus, nucleolus : Q969H0 |
Total number of polymer chains | 3 |
Total formula weight | 69227.36 |
Authors | Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P. (deposition date: 2007-02-14, release date: 2007-04-24, Last modification date: 2024-04-03) |
Primary citation | Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P. Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26:131-143, 2007 Cited by PubMed: 17434132DOI: 10.1016/j.molcel.2007.02.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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