1C9F
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3TMH
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![BU of 3tmh by Molmil](/molmil-images/mine/3tmh) | Crystal structure of dual-specific A-kinase anchoring protein 2 in complex with cAMP-dependent protein kinase A type II alpha and PDZK1 | Descriptor: | A-kinase anchor protein 10, mitochondrial, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, ... | Authors: | Sarma, G.N, Phan, R.H, Sankaran, B, Taylor, S.S. | Deposit date: | 2011-08-31 | Release date: | 2012-09-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Differential mode of D-AKAP2 to PKA isoforms: Insights from D-AKAP2 PKA RII PDZK1 ternary complex structure To be Published
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4CK7
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![BU of 4ck7 by Molmil](/molmil-images/mine/4ck7) | Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | Deposit date: | 2013-12-30 | Release date: | 2014-02-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9.2 Å) | Cite: | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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5COE
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![BU of 5coe by Molmil](/molmil-images/mine/5coe) | The structure of the NK1 fragment of HGF/SF complexed with HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Ascher, D.B, Chirgadze, D.Y, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-20 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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1NIW
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![BU of 1niw by Molmil](/molmil-images/mine/1niw) | Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Nitric-oxide synthase, ... | Authors: | Aoyagi, M, Arvai, A.S, Tainer, J.A, Getzoff, E.D. | Deposit date: | 2002-12-26 | Release date: | 2003-02-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for endothelial nitric oxide synthase binding to calmodulin Embo J., 22, 2003
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4CK5
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![BU of 4ck5 by Molmil](/molmil-images/mine/4ck5) | Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | Deposit date: | 2013-12-30 | Release date: | 2014-02-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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5CNQ
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![BU of 5cnq by Molmil](/molmil-images/mine/5cnq) | Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions | Descriptor: | DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ... | Authors: | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | Deposit date: | 2015-07-17 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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5CO1
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1TZ8
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![BU of 1tz8 by Molmil](/molmil-images/mine/1tz8) | The monoclinic crystal structure of transthyretin in complex with diethylstilbestrol | Descriptor: | ACETATE ION, CARBONATE ION, DIETHYLSTILBESTROL, ... | Authors: | Morais-de-Sa, E.M, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. | Deposit date: | 2004-07-09 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors J.Biol.Chem., 279, 2004
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3DGA
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![BU of 3dga by Molmil](/molmil-images/mine/3dga) | Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide, ... | Authors: | Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S. | Deposit date: | 2008-06-13 | Release date: | 2009-01-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chem.Biol., 4, 2009
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3SOA
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![BU of 3soa by Molmil](/molmil-images/mine/3soa) | Full-length human CaMKII | Descriptor: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | Authors: | Chao, L.H, Kuriyan, J. | Deposit date: | 2011-06-30 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.5501 Å) | Cite: | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell(Cambridge,Mass.), 146, 2011
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3DX8
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![BU of 3dx8 by Molmil](/molmil-images/mine/3dx8) | Crystal Structure of B*4405 presenting a 10mer EBV epitope | Descriptor: | Beta-2-microglobulin, EBV decapeptide epitope, GLYCEROL, ... | Authors: | Archbold, J.K, Ely, L.K, Rossjohn, J. | Deposit date: | 2008-07-23 | Release date: | 2009-01-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J.Exp.Med., 206, 2009
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1YR5
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3DXA
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![BU of 3dxa by Molmil](/molmil-images/mine/3dxa) | Crystal Structure of the DM1 TCR in complex with HLA-B*4405 and decamer EBV antigen | Descriptor: | Beta-2-microglobulin, DM1 T cell receptor alpha chain, DM1 T cell receptor beta chain, ... | Authors: | Archbold, J.K, Macdonald, W.A, Gras, S, Rossjohn, J. | Deposit date: | 2008-07-23 | Release date: | 2009-01-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J.Exp.Med., 206, 2009
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5CO8
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![BU of 5co8 by Molmil](/molmil-images/mine/5co8) | Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion | Descriptor: | DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ... | Authors: | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | Deposit date: | 2015-07-20 | Release date: | 2016-01-13 | Last modified: | 2018-11-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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5T8N
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4DJC
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![BU of 4djc by Molmil](/molmil-images/mine/4djc) | 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex | Descriptor: | CALCIUM ION, Calmodulin, ISOPROPYL ALCOHOL, ... | Authors: | Sarhan, M.F, Tung, C.-C, Van Petegem, F, Ahern, C.A. | Deposit date: | 2012-02-01 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Crystallographic basis for calcium regulation of sodium channels. Proc.Natl.Acad.Sci.USA, 109, 2012
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5CSQ
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![BU of 5csq by Molmil](/molmil-images/mine/5csq) | The structure of the NK1 fragment of HGF/SF complexed with MOPS | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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5CS9
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![BU of 5cs9 by Molmil](/molmil-images/mine/5cs9) | The structure of the NK1 fragment of HGF/SF complexed with MES | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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5CT1
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![BU of 5ct1 by Molmil](/molmil-images/mine/5ct1) | The structure of the NK1 fragment of HGF/SF complexed with CHES | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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5UZ9
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![BU of 5uz9 by Molmil](/molmil-images/mine/5uz9) | Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | Descriptor: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | Authors: | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | Deposit date: | 2017-02-25 | Release date: | 2017-04-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell, 169, 2017
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5CS1
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![BU of 5cs1 by Molmil](/molmil-images/mine/5cs1) | The structure of the NK1 fragment of HGF/SF | Descriptor: | Hepatocyte growth factor | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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5V35
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![BU of 5v35 by Molmil](/molmil-images/mine/5v35) | Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2017-03-06 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5URH
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![BU of 5urh by Molmil](/molmil-images/mine/5urh) | CYPOR/D632A with NADP+ | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Xia, C, Kim, J.J. | Deposit date: | 2017-02-10 | Release date: | 2018-02-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer. Biochemistry, 57, 2018
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5CS5
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![BU of 5cs5 by Molmil](/molmil-images/mine/5cs5) | The structure of the NK1 fragment of HGF/SF complexed with PIPES | Descriptor: | Hepatocyte growth factor, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) | Authors: | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | Deposit date: | 2015-07-23 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
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