4Y2Y
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6EDB
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![BU of 6edb by Molmil](/molmil-images/mine/6edb) | Crystal structure of SRY.hcGAS-21bp dsDNA complex | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), Sex-determining region Y protein,Cyclic GMP-AMP synthase, ... | Authors: | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | Deposit date: | 2018-08-09 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.209 Å) | Cite: | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116, 2019
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4XZE
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![BU of 4xze by Molmil](/molmil-images/mine/4xze) | The crystal structure of Hazara virus nucleoprotein | Descriptor: | Nucleoprotein | Authors: | Guo, Y, Wang, W, Liu, X, Wang, X, Wang, J, Huo, T, Liu, B. | Deposit date: | 2015-02-04 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins. J.Virol., 89, 2015
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4Y2U
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![BU of 4y2u by Molmil](/molmil-images/mine/4y2u) | Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Descriptor: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate | Authors: | Amano, Y, Yamaguchi, T. | Deposit date: | 2015-02-10 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
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5CB3
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![BU of 5cb3 by Molmil](/molmil-images/mine/5cb3) | Structural Insights into the Mechanism of Escherichia coli Ymdb | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, O-acetyl-ADP-ribose deacetylase | Authors: | Zhang, W, Wang, C, Song, Y, Shao, C, Zhang, X, Zang, J. | Deposit date: | 2015-06-30 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase J.Struct.Biol., 192, 2015
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7Z1X
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4Y2J
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5CKQ
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![BU of 5ckq by Molmil](/molmil-images/mine/5ckq) | CUB1-EGF-CUB2 domains of rat MASP-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine protease 1, ... | Authors: | Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J. | Deposit date: | 2015-07-15 | Release date: | 2017-01-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.704 Å) | Cite: | Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Structure, 25, 2017
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4Y2P
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6Y5E
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![BU of 6y5e by Molmil](/molmil-images/mine/6y5e) | Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex) | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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7YW5
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4Y2T
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4Y7E
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![BU of 4y7e by Molmil](/molmil-images/mine/4y7e) | Crystal structure of beta-mannanase from Streptomyces thermolilacinus with mannohexaose | Descriptor: | CALCIUM ION, Endoglucanase, GLYCEROL, ... | Authors: | Kumagai, Y, Yamashita, K, Okuyama, M, Hatanaka, T, Yao, M, Kimura, A. | Deposit date: | 2015-02-14 | Release date: | 2015-09-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The loop structure of Actinomycete glycoside hydrolase family 5 mannanases governs substrate recognition Febs J., 282, 2015
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8A3B
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6Y5D
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![BU of 6y5d by Molmil](/molmil-images/mine/6y5d) | Structure of human cGAS (K394E) bound to the nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
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5CB5
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![BU of 5cb5 by Molmil](/molmil-images/mine/5cb5) | Structural Insights into the Mechanism of Escherichia coli Ymdb | Descriptor: | ACETATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, O-acetyl-ADP-ribose deacetylase, ... | Authors: | Zhang, W, Wang, C, Song, Y, Shao, C, Zhang, X, Zang, J. | Deposit date: | 2015-06-30 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase J.Struct.Biol., 192, 2015
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5CON
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![BU of 5con by Molmil](/molmil-images/mine/5con) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-015 | Descriptor: | (3R,3aS,4S,7aS)-3-hydroxyhexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, HIV-1 protease | Authors: | Yedidi, R.S, Hayashi, H, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2015-07-20 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. J.Virol., 90, 2015
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5COO
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![BU of 5coo by Molmil](/molmil-images/mine/5coo) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-085 | Descriptor: | (3R,3aS,4S,7aS)-3-hydroxyhexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-1-(4-methoxyphenyl)-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}butan-2-yl]carbamate, HIV-1 protease | Authors: | Yedidi, R.S, Hayashi, H, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2015-07-20 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. J.Virol., 90, 2015
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5CMS
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![BU of 5cms by Molmil](/molmil-images/mine/5cms) | Structural Insights into the Mechanism of Escherichia coli Ymdb | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, O-acetyl-ADP-ribose deacetylase, SULFATE ION | Authors: | Zhang, W, Wang, C, Song, Y, Shao, C, Zhang, X, Zang, J. | Deposit date: | 2015-07-17 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase J.Struct.Biol., 192, 2015
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5CXO
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![BU of 5cxo by Molmil](/molmil-images/mine/5cxo) | Intriguing role of epoxide hydrolase/cyclase-like enzyme SalBIII in pyran ring formation in polyether salinomycin | Descriptor: | Epoxide hydrolase, HEXAETHYLENE GLYCOL | Authors: | Dias, M.V.B, Luhavaya, H, Williams, S.R, Hong, H, Oliveira, L.G, Leadlay, P.F. | Deposit date: | 2015-07-29 | Release date: | 2015-09-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 54, 2015
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4WZP
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![BU of 4wzp by Molmil](/molmil-images/mine/4wzp) | Ser65 phosphorylated ubiquitin, major conformation | Descriptor: | SULFATE ION, ubiquitin | Authors: | Wauer, T, Wagstaff, J, Freund, S.M.V, Komander, D. | Deposit date: | 2014-11-20 | Release date: | 2015-01-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. Embo J., 34, 2015
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8A28
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6XJD
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![BU of 6xjd by Molmil](/molmil-images/mine/6xjd) | Two mouse cGAS catalytic domain binding to human assembled nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA (145-MER), Histone H2A type 1, ... | Authors: | Xu, P, Li, P, Zhao, B. | Deposit date: | 2020-06-23 | Release date: | 2020-09-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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4Y2S
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4Y2V
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