7Z1X

Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6

Summary for 7Z1X

• Entry DOI: 10.2210/pdb7z1x/pdb
• Descriptor: Gasdermin-D, VHH-2, VHH-6, ... (4 entities in total)
• Functional Keywords: gasdermin d, gsdmd, nanobody, vhh, inflammation, pyroptosis, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 157390.29

Authors

Kopp, A.,Hagelueken, G.,Geyer, M. (deposition date: 2022-02-25, release date: 2023-09-06, Last modification date: 2023-12-13)

• Primary citation: Kopp, A.,Hagelueken, G.,Jamitzky, I.,Moecking, J.,Schiffelers, L.D.J.,Schmidt, F.I.,Geyer, M.; Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.; Nat Commun, 14:7923-7923, 2023; PubMed: 38040708; DOI: 10.1038/s41467-023-43707-z

Experimental method

X-RAY DIFFRACTION (1.86 Å)