7Z1X

Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006351	biological_process	DNA-templated transcription
A	0006954	biological_process	inflammatory response
A	0008289	molecular_function	lipid binding
A	0009306	biological_process	protein secretion
A	0012501	biological_process	programmed cell death
A	0016020	cellular_component	membrane
A	0022829	molecular_function	wide pore channel activity
A	0031966	cellular_component	mitochondrial membrane
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0035580	cellular_component	specific granule lumen
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0046931	biological_process	pore complex assembly
A	0050729	biological_process	positive regulation of inflammatory response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	0061702	cellular_component	canonical inflammasome complex
A	0070269	biological_process	pyroptotic inflammatory response
A	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
A	0070300	molecular_function	phosphatidic acid binding
A	0072559	cellular_component	NLRP3 inflammasome complex
A	0141201	biological_process	pyroptotic cell death
A	1901612	molecular_function	cardiolipin binding
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
D	0001786	molecular_function	phosphatidylserine binding
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006351	biological_process	DNA-templated transcription
D	0006954	biological_process	inflammatory response
D	0008289	molecular_function	lipid binding
D	0009306	biological_process	protein secretion
D	0012501	biological_process	programmed cell death
D	0016020	cellular_component	membrane
D	0022829	molecular_function	wide pore channel activity
D	0031966	cellular_component	mitochondrial membrane
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0035580	cellular_component	specific granule lumen
D	0042742	biological_process	defense response to bacterium
D	0045087	biological_process	innate immune response
D	0046931	biological_process	pore complex assembly
D	0050729	biological_process	positive regulation of inflammatory response
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	0061702	cellular_component	canonical inflammasome complex
D	0070269	biological_process	pyroptotic inflammatory response
D	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
D	0070300	molecular_function	phosphatidic acid binding
D	0072559	cellular_component	NLRP3 inflammasome complex
D	0141201	biological_process	pyroptotic cell death
D	1901612	molecular_function	cardiolipin binding
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Region: {"description":"Linker helix loop","evidences":[{"source":"PubMed","id":"28928145","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Cleavage; by caspases CASP1, CASP4, CASP5 and CASP8","evidences":[{"source":"PubMed","id":"26375003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32109412","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38599239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29898893","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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