7Z1X
Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Gasdermin-D | polymer | 447 | 48818.1 | 2 | UniProt (P57764) Pfam (PF04598) Pfam (PF17708) | Homo sapiens (human) | Gasdermin domain-containing protein 1 |
| 2 | B, E (B, E) | VHH-2 | polymer | 132 | 14457.9 | 2 | Lama glama | ||
| 3 | C, F (C, F) | VHH-6 | polymer | 141 | 15419.1 | 2 | Lama glama | ||
| 4 | G, H, I, J, K... (A, B, C, D, E...) | water | water | 18.0 | 557 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 484 (UniProt: P57764)
| PDB | External Database | Details |
|---|---|---|
| - | Phe 184 | deletion |
| - | Ser 185 | deletion |
| - | Leu 186 | deletion |
| - | Pro 187 | deletion |
| - | Gly 188 | deletion |
| - | Ala 189 | deletion |
| - | Thr 190 | deletion |
| - | Cys 191 | deletion |
| - | Leu 192 | deletion |
| - | Gln 193 | deletion |
| - | Gly 194 | deletion |
| - | His 247 | deletion |
| - | Lys 248 | deletion |
| - | Arg 249 | deletion |
| - | Ser 250 | deletion |
| - | Thr 251 | deletion |
| - | Ser 252 | deletion |
| - | Glu 253 | deletion |
| - | Gly 254 | deletion |
| - | Ala 255 | deletion |
| - | Trp 256 | deletion |
| - | Pro 257 | deletion |
| - | Gln 258 | deletion |
| - | Leu 259 | deletion |
| - | Pro 260 | deletion |
| - | Ser 261 | deletion |
| - | Gly 262 | deletion |
| - | Leu 263 | deletion |
| - | Ser 264 | deletion |
| - | Met 265 | deletion |
| - | Met 266 | deletion |
| - | Arg 267 | deletion |
| - | Cys 268 | deletion |
| - | Leu 269 | deletion |
| - | His 270 | deletion |
| - | Asn 271 | deletion |
| - | Phe 272 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 157390.3 | |
| All* | Total formula weight | 157390.3 |
