6EDB
Crystal structure of SRY.hcGAS-21bp dsDNA complex
Summary for 6EDB
Entry DOI | 10.2210/pdb6edb/pdb |
Descriptor | Sex-determining region Y protein,Cyclic GMP-AMP synthase, DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), ... (4 entities in total) |
Functional Keywords | sry human cgas dna complex, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 121003.03 |
Authors | Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2018-08-09, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Xie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019 Cited by PubMed: 31142647DOI: 10.1073/pnas.1905013116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.209 Å) |
Structure validation
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