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6EDB

Crystal structure of SRY.hcGAS-21bp dsDNA complex

Summary for 6EDB
Entry DOI10.2210/pdb6edb/pdb
DescriptorSex-determining region Y protein,Cyclic GMP-AMP synthase, DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), ... (4 entities in total)
Functional Keywordssry human cgas dna complex, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight121003.03
Authors
Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2018-08-09, release date: 2019-05-29, Last modification date: 2023-10-11)
Primary citationXie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019
Cited by
PubMed: 31142647
DOI: 10.1073/pnas.1905013116
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.209 Å)
Structure validation

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