6EDB

Crystal structure of SRY.hcGAS-21bp dsDNA complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Sex-determining region Y protein,Cyclic GMP-AMP synthase	polymer	455	53716.9	2	UniProt (Q05066) UniProt (Q8N884) Pfam (PF00505) Pfam (PF03281) Pfam (PF20266) In PDB	Homo sapiens (Human)	Testis-determining factor,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C	DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3')	polymer	22	6745.4	1		Homo sapiens
3	D	DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3')	polymer	22	6758.4	1		Homo sapiens
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A, B: 69 - 143 (UniProt: Q05066)

PDB	External Database	Details
Ser 68	-	expression tag
Lys 144	-	linker
Gly 145	-	linker
Glu 146	-	linker
Thr 147	-	linker
Lys 148	-	linker
Lys 149	-	linker
Lys 150	-	linker
Phe 151	-	linker
Lys 152	-	linker
Asp 153	-	linker
Pro 154	-	linker
Asn 155	-	linker
Ala 156	-	linker

A, B: 157 - 522 (UniProt: Q8N884)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	120937.6
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	121003.0

*Water molecules are not included.