6EDB
Crystal structure of SRY.hcGAS-21bp dsDNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sex-determining region Y protein,Cyclic GMP-AMP synthase | polymer | 455 | 53716.9 | 2 | UniProt (Q05066) UniProt (Q8N884) Pfam (PF00505) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | Testis-determining factor,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C (C) | DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3') | polymer | 22 | 6745.4 | 1 | Homo sapiens | ||
| 3 | D (D) | DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3') | polymer | 22 | 6758.4 | 1 | Homo sapiens | ||
| 4 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, B: 69 - 143 (UniProt: Q05066)
A, B: 157 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | - | expression tag |
| Lys 144 | - | linker |
| Gly 145 | - | linker |
| Glu 146 | - | linker |
| Thr 147 | - | linker |
| Lys 148 | - | linker |
| Lys 149 | - | linker |
| Lys 150 | - | linker |
| Phe 151 | - | linker |
| Lys 152 | - | linker |
| Asp 153 | - | linker |
| Pro 154 | - | linker |
| Asn 155 | - | linker |
| Ala 156 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 120937.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 121003.0 |
