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8F9F	Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NANP3 peptide Descriptor: 1,2-ETHANEDIOL, Circumsporozoite protein NANP peptide, Ky15.2 Antibody, ... Authors: Thai, E, Julien, J.P. Deposit date: 2022-11-23 Release date: 2023-11-01 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep, 42, 2023
2YSS	Crystal structure of Humanized HYHEL-10 FV mutant(HQ39KW47Y)-HEN lysozyme complex Descriptor: ANTI-LYSOZYME ANTIBODY FV REGION, Lysozyme C Authors: Nakanishi, T, Tsumoto, K, Yokota, A, Kondo, H, Kumagai, I. Deposit date: 2007-04-03 Release date: 2008-04-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10 Protein Sci., 17, 2008
8DB4	Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Descriptor: 1,2-ETHANEDIOL, 13T1 Heavy chain, 13T1 Light chain, ... Authors: Min, J, Pedersen, L.C. Deposit date: 2022-06-14 Release date: 2023-01-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy. J.Clin.Invest., 133, 2023
2RCS	IMMUNOGLOBULIN 48G7 GERMLINE FAB-AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY Descriptor: IMMUNOGLOBULIN 48G7 GERMLINE FAB Authors: Wedemayer, G.J, Wang, L.H, Patten, P.A, Schultz, P.G, Stevens, R.C. Deposit date: 1997-05-14 Release date: 1997-11-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into the evolution of an antibody combining site. Science, 276, 1997
2OJZ	Anti-DNA antibody ED10 Descriptor: Fab ED10 heavy chain, Fab ED10 light chain Authors: Stanfield, R.L, Sanguineti, S, Wilson, I.A, de Prat-Gay, G. Deposit date: 2007-01-15 Release date: 2007-06-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Specific recognition of a DNA immunogen by its elicited antibody J.Mol.Biol., 370, 2007
6B3M	The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 70-1F02 Fab Heavy Chain, ... Authors: Shore, D.A, Yang, H, Stevens, J. Deposit date: 2017-09-22 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.92 Å) Cite: Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge. J. Virol., 92, 2018
7Y3J	24B3 antibody-peptide complex Descriptor: 24B3 Heavy chain, 24B3 Light chain, ALA-LEU-VAL-PHE-PHE-ALA-PRO-ALA-VAL-GLY-SER Authors: Irie, K, Irie, Y, Kita, A, Miki, K. Deposit date: 2022-06-11 Release date: 2022-08-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of the 24B3 antibody against the toxic conformer of amyloid beta with a turn at positions 22 and 23. Biochem.Biophys.Res.Commun., 621, 2022
2O5X	Crystal structure of 1E9 LeuH47Trp/ArgH100Trp, an engineered Diels-Alderase Fab with nM steroid-binding affinity Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, chimeric antibody Fab 1E9-DB3 Authors: Verdino, P, Wilson, I.A. Deposit date: 2006-12-06 Release date: 2007-12-18 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Closely related antibody receptors exploit fundamentally different strategies for steroid recognition. Proc.Natl.Acad.Sci.Usa, 105, 2008
1UB5	Crystal structure of Antibody 19G2 with hapten at 100K Descriptor: 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID, antibody 19G2, alpha chain, ... Authors: Beuscher, A.B, Wirsching, P, Lerner, R.A, Janda, K, Stevens, R.C. Deposit date: 2003-03-30 Release date: 2004-04-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure and Dynamics of Blue Fluorescent Antibody 19G2 at Blue and Violet Fluorescent Temperatures To be published
4NHC	Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41. Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41), ... Authors: Irimia, A, Wilson, I.A. Deposit date: 2013-11-04 Release date: 2014-12-03 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.912 Å) Cite: Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat.Struct.Mol.Biol., 21, 2014
4NGH	Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41 and a tethered phosphate moiety. Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41) Authors: Irimia, A, Wilson, I.A. Deposit date: 2013-11-01 Release date: 2014-12-03 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat.Struct.Mol.Biol., 21, 2014
6BCK	Crystal Structure of Broadly Neutralizing Antibody N49P7 in Complex with HIV-1 Clade AE strain 93TH057 gp120 core. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N49P7 Fab heavy chain of N29P7 IgG, ... Authors: Tolbert, W.D, Gohain, N, Pazgier, M. Deposit date: 2017-10-20 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses. Cell, 173, 2018
2GJZ	Structure of Catalytic Elimination Antibody 13G5 from a crystal in space group P2(1) Descriptor: Catalytic elimination antibody 13G5 heavy chain, Catalytic elimination antibody 13G5 light chain, ZINC ION Authors: Debler, E.W, Wilson, I.A. Deposit date: 2006-03-31 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Bifunctional Catalysis of Proton Transfer at an Antibody Active Site. J.Am.Chem.Soc., 129, 2007
2GK0	Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2 Descriptor: Catalytic elimination antibody 13G5 heavy chain, Catalytic elimination antibody 13G5 light chain Authors: Debler, E.W, Wilson, I.A. Deposit date: 2006-03-31 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Bifunctional Catalysis of Proton Transfer at an Antibody Active Site. J.Am.Chem.Soc., 129, 2007
7CM4	Crystal Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody CT-P59 Descriptor: 1,2-ETHANEDIOL, IgG heavy chain, IgG light chain, ... Authors: Kim, Y.G, Jeong, J.H, Bae, J.S, Lee, J. Deposit date: 2020-07-24 Release date: 2021-01-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. Nat Commun, 12, 2021
7QXC	Recognition of Staphylococcus aureus wall teichoic acid analogue SA533 (compound 1) by Fab4461 Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, DI(HYDROXYETHYL)ETHER, Fab 4461 heavy chain, ... Authors: Soriano-Maldonado, P, van Raaij, M.J. Deposit date: 2022-01-26 Release date: 2022-08-31 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.452 Å) Cite: Antibody Recognition of Different Staphylococcus aureus Wall Teichoic Acid Glycoforms. Acs Cent.Sci., 8, 2022
7RAJ	Structure of PfCSP peptide 21 with antibody iGL-CIS43.D3 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN-ALA-ASN, ZINC ION, ... Authors: Tripathi, P, Kwong, P.D. Deposit date: 2021-07-01 Release date: 2021-12-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54, 2021
7M7B	SARS-CoV-2 Spike:Fab 3D11 complex focused refinement Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 3D11 heavy chain, Antibody Fab 3D11 light chain, ... Authors: Asarnow, D, Cheng, Y. Deposit date: 2021-03-27 Release date: 2021-05-26 Last modified: 2021-06-23 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell, 184, 2021
8B7H	Crystal structure of human Gremlin-1 in complex with Fab Descriptor: Fab antibody fragment (heavy chain), Fab antibody fragment (light chain), Gremlin-1 Authors: Schulze, M.-S, Martinez-Fleites, C. Deposit date: 2022-09-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer. Mabs, 15, 2023
1NBV	AN AUTOANTIBODY TO SINGLE-STRANDED DNA: COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE-FAB COMPLEX Descriptor: IGG2B-KAPPA BV04-01 FAB (HEAVY CHAIN), IGG2B-KAPPA BV04-01 FAB (LIGHT CHAIN) Authors: Herron, J.N, He, X.M, Edmundson, A.B. Deposit date: 1993-03-16 Release date: 1994-01-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2 Å) Cite: An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins, 11, 1991
3MOD	Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide Descriptor: ANTI-HIV-1 ANTIBODY 2F5 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 2F5 LIGHT CHAIN, gp41 MPER-derived peptide Authors: Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. Deposit date: 2010-04-22 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
3MOB	Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced Fab) with 11 aa gp41 MPER-derived peptide Descriptor: ANTI-HIV-1 ANTIBODY 2F5 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 2F5 LIGHT CHAIN, gp41 MPER-derived peptide Authors: Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. Deposit date: 2010-04-22 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
3MOA	Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced Fab) with 17 aa gp41 MPER-derived peptide Descriptor: ANTI-HIV-1 ANTIBODY 2F5 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 2F5 LIGHT CHAIN, gp41 MPER-derived peptide Authors: Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. Deposit date: 2010-04-22 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
3MO1	Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment Descriptor: ACETATE ION, ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, ... Authors: Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. Deposit date: 2010-04-22 Release date: 2010-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
2R2H	Structure of S25-2 in Complex with Ko Descriptor: Fab, antibody fragment (IgG1k), heavy chain, ... Authors: Brooks, C.L, Evans, S.V. Deposit date: 2007-08-25 Release date: 2008-12-30 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J.Mol.Biol., 377, 2008

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