8B7H

Crystal structure of human Gremlin-1 in complex with Fab

Summary for 8B7H

• Entry DOI: 10.2210/pdb8b7h/pdb
• Descriptor: Fab antibody fragment (light chain), Fab antibody fragment (heavy chain), Gremlin-1, ... (4 entities in total)
• Functional Keywords: inhibitor, glycoprotein, cysteine knot-secreted protein, signaling protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 64687.39

Authors

Schulze, M.-S.,Martinez-Fleites, C. (deposition date: 2022-09-30, release date: 2023-12-27)

• Primary citation: Davies, G.C.G.,Dedi, N.,Jones, P.S.,Kevorkian, L.,McMillan, D.,Ottone, C.,Schulze, M.E.D.,Scott-Tucker, A.,Tewari, R.,West, S.,Wright, M.,Rowley, T.F.; Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer.; Mabs, 15:2289681-2289681, 2023; PubMed: 38084840; DOI: 10.1080/19420862.2023.2289681

Experimental method

X-RAY DIFFRACTION (1.95 Å)