8B7H

Crystal structure of human Gremlin-1 in complex with Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L)	Fab antibody fragment (light chain)	polymer	219	24197.8	1		Homo sapiens
2	B (H)	Fab antibody fragment (heavy chain)	polymer	227	24271.0	1		Homo sapiens
3	C (A)	Gremlin-1	polymer	139	16218.6	1	UniProt (O60565) Pfam (PF03045)	Homo sapiens (human)	Cell proliferation-inducing gene 2 protein,Cysteine knot superfamily 1,BMP antagonist 1,DAN domain family member 2,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2
4	D, E (L, H)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A: 46 - 163 (UniProt: O60565)

PDB	External Database	Details
Met 25	-	initiating methionine
Gly 26	-	expression tag
Ser 27	-	expression tag
Ser 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
Ser 35	-	expression tag
Ser 36	-	expression tag
Gly 37	-	expression tag
Glu 38	-	expression tag
Asn 39	-	expression tag
Leu 40	-	expression tag
Tyr 41	-	expression tag
Phe 42	-	expression tag
Gln 43	-	expression tag
Gly 44	-	expression tag
Ser 45	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	64687.4
All*	Total formula weight	64687.4

*Water molecules are not included.