2O5X

Crystal structure of 1E9 LeuH47Trp/ArgH100Trp, an engineered Diels-Alderase Fab with nM steroid-binding affinity

Summary for 2O5X

• Entry DOI: 10.2210/pdb2o5x/pdb
• Related: 2O5Y 2O5Z
• Descriptor: chimeric antibody Fab 1E9-DB3, SULFATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: immunoglobulin, chimeric fab, antibody engineering, evolution of ligand recognition, immune system
• Biological source: Mus musculus, Homo sapiens (house mouse, human); More
• Total number of polymer chains: 2
• Total formula weight: 49747.36

Authors

Verdino, P.,Wilson, I.A. (deposition date: 2006-12-06, release date: 2007-12-18, Last modification date: 2023-08-30)

• Primary citation: Verdino, P.,Aldag, C.,Hilvert, D.,Wilson, I.A.; Closely related antibody receptors exploit fundamentally different strategies for steroid recognition.; Proc.Natl.Acad.Sci.Usa, 105:11725-11730, 2008; PubMed: 18689687; DOI: 10.1073/pnas.0801783105

Experimental method

X-RAY DIFFRACTION (2.05 Å)