7YCG
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![BU of 7ycg by Molmil](/molmil-images/mine/7ycg) | Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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4FAU
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![BU of 4fau by Molmil](/molmil-images/mine/4fau) | Structure of Oceanobacillus iheyensis group II intron in the presence of Li+, Mg2+ and 5'-exon | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Group IIC intron, MAGNESIUM ION, ... | Authors: | Marcia, M, Pyle, A.M. | Deposit date: | 2012-05-22 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Visualizing Group II Intron Catalysis through the Stages of Splicing. Cell(Cambridge,Mass.), 151, 2012
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4FAW
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![BU of 4faw by Molmil](/molmil-images/mine/4faw) | Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and a hydrolyzed oligonucleotide fragment | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-R(*A*UP*UP*UP*AP*UP*UP*A)-3', Group IIC intron, ... | Authors: | Marcia, M, Pyle, A.M. | Deposit date: | 2012-05-22 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Visualizing Group II Intron Catalysis through the Stages of Splicing. Cell(Cambridge,Mass.), 151, 2012
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2K87
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![BU of 2k87 by Molmil](/molmil-images/mine/2k87) | NMR STRUCTURE OF A PUTATIVE RNA BINDING PROTEIN (SARS1) FROM SARS CORONAVIRUS | Descriptor: | Non-structural protein 3 of Replicase polyprotein 1a | Authors: | Serrano, P, Wuthrich, K, Johnson, M.A, Chatterjee, A, Wilson, I, Pedrini, B.F, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2008-09-02 | Release date: | 2008-09-16 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3. J.Virol., 83, 2009
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1DDL
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![BU of 1ddl by Molmil](/molmil-images/mine/1ddl) | DESMODIUM YELLOW MOTTLE TYMOVIRUS | Descriptor: | DESMODIUM YELLOW MOTTLE VIRUS, RNA (5'-R(P*UP*U)-3'), RNA (5'-R(P*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Larson, S.B, Day, J, Canady, M.A, Greenwood, A, McPherson, A. | Deposit date: | 1999-11-10 | Release date: | 2000-10-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Refined structure of desmodium yellow mottle tymovirus at 2.7 A resolution. J.Mol.Biol., 301, 2000
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7YCH
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![BU of 7ych by Molmil](/molmil-images/mine/7ych) | Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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104D
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![BU of 104d by Molmil](/molmil-images/mine/104d) | |
2M17
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![BU of 2m17 by Molmil](/molmil-images/mine/2m17) | |
7K5D
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![BU of 7k5d by Molmil](/molmil-images/mine/7k5d) | Ebola virus VP40 octameric ring generated by a DNA oligonucleotide | Descriptor: | HSP DNA oligonucleotide, Matrix protein VP40 | Authors: | Landeras-Bueno, S, Wasserman, H, Salie, Z.L, Saphire, E.O. | Deposit date: | 2020-09-16 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form. Cell Rep, 35, 2021
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7DSY
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![BU of 7dsy by Molmil](/molmil-images/mine/7dsy) | Crystal Structure of RNase L in complex with KM05073 | Descriptor: | 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, ... | Authors: | Tang, J, Huang, H. | Deposit date: | 2021-01-03 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65, 2022
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7DTS
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![BU of 7dts by Molmil](/molmil-images/mine/7dts) | Crystal structure of RNase L in complex with AC40357 | Descriptor: | 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, Ribonuclease L, ... | Authors: | Tang, J, Huang, H. | Deposit date: | 2021-01-06 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65, 2022
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7ELW
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![BU of 7elw by Molmil](/molmil-images/mine/7elw) | Crystal structure of RNase L in complex with Myricetin | Descriptor: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, PHOSPHATE ION, Ribonuclease L, ... | Authors: | Tang, J, Huang, H. | Deposit date: | 2021-04-12 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65, 2022
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2O43
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![BU of 2o43 by Molmil](/molmil-images/mine/2o43) | Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide erythromycylamine | Descriptor: | (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-AMINO-6-{[(2S,3R,4S,6R)-4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PY RAN-2-YL]OXY}-14-ETHYL-7,12,13-TRIHYDROXY-4-{[(2R,4R,5S,6S)-5-HYDROXY-4-METHOXY-4,6-DIMETHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY }-3,5,7,9,11,13-HEXAMETHYLOXACYCLOTETRADECAN-2-ONE, 23S rRNA | Authors: | Pyetan, E, Baram, D, Auerbach-Nevo, T, Yonath, A. | Deposit date: | 2006-12-03 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel TO BE PUBLISHED
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2O44
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![BU of 2o44 by Molmil](/molmil-images/mine/2o44) | Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide josamycin | Descriptor: | (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10S,12E,14Z,16R)-4-(ACETYLOXY)-10-HYDROXY-5-METHOXY-9,16-DIMETHYL-2-OXO-7-(2-OXOETHYL)OXACYCLOHEXADECA-12,14-DIEN-6-YL]OXY}-4-(DIMETHYLAMINO)-5-HYDROXY-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL]OXY}-4-HYDROXY-2,4-DIMETHYLTETRAHYDRO-2H-PYRAN-3-YL 3-METHYLBUTANOATE, 23S rRNA | Authors: | Pyetan, E, Daram, D, Auerbach-Nevo, T, Yonath, A. | Deposit date: | 2006-12-03 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel TO BE PUBLISHED
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4GSP
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![BU of 4gsp by Molmil](/molmil-images/mine/4gsp) | RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS + 3'-GMP, 7 DAYS | Descriptor: | CALCIUM ION, GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, GUANOSINE-3'-MONOPHOSPHATE, ... | Authors: | Zegers, I, Wyns, L. | Deposit date: | 1997-12-02 | Release date: | 1998-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. Nat.Struct.Biol., 5, 1998
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2O45
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![BU of 2o45 by Molmil](/molmil-images/mine/2o45) | Structure of the 23S rRNA of the large ribosomal subunit from Deinococcus Radiodurans in complex with the macrolide RU-69874 | Descriptor: | (3AS,4R,7R,8S,9S,10R,11R,13R,15R,15AR)-4-ETHYL-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-2,6,14-TRIOXO-1-[4-(4-PYRIDIN-3-YL-1H-IMIDAZOL-1-YL)BUTYL]-10-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}TETRADECAHYDRO-2H-OXACYCLOTETRADECINO[4,3-D][1,3]OXAZOL-8-YL 2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE, 23S rRNA | Authors: | Baram, D, Pyetan, E, Auerbach-Nevo, T, Yonath, A. | Deposit date: | 2006-12-03 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Chemical Parameters Influencing Fine Tuning in the Binding of Macrolide Antibiotics to the Ribosomal Tunnel TO BE PUBLISHED
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4Q2S
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![BU of 4q2s by Molmil](/molmil-images/mine/4q2s) | |
6HT4
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![BU of 6ht4 by Molmil](/molmil-images/mine/6ht4) | |
1V39
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![BU of 1v39 by Molmil](/molmil-images/mine/1v39) | |
1BYJ
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![BU of 1byj by Molmil](/molmil-images/mine/1byj) | GENTAMICIN C1A A-SITE COMPLEX | Descriptor: | 2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose, 3,5-DIAMINO-CYCLOHEXANOL, 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranose, ... | Authors: | Yoshizawa, S, Fourmy, D, Puglisi, J.D. | Deposit date: | 1998-10-16 | Release date: | 1999-10-29 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural origins of gentamicin antibiotic action. EMBO J., 17, 1998
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3PJ8
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![BU of 3pj8 by Molmil](/molmil-images/mine/3pj8) | Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine. | Descriptor: | (2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-ol, Cell division protein kinase 2 | Authors: | McNae, I.W, Jorda, R, Havlicek, L, Strnad, M, Voller, J, Walkinshaw, M.D, Krystof, V. | Deposit date: | 2010-11-09 | Release date: | 2011-04-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity. J.Med.Chem., 54, 2011
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3Q7B
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![BU of 3q7b by Molmil](/molmil-images/mine/3q7b) | Exonuclease domain of Lassa virus nucleoprotein | Descriptor: | Nucleoprotein, PHOSPHATE ION, ZINC ION | Authors: | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | Deposit date: | 2011-01-04 | Release date: | 2011-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc.Natl.Acad.Sci.USA, 108, 2011
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4AK9
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![BU of 4ak9 by Molmil](/molmil-images/mine/4ak9) | |
1DVK
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![BU of 1dvk by Molmil](/molmil-images/mine/1dvk) | |
2L5C
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![BU of 2l5c by Molmil](/molmil-images/mine/2l5c) | |