2O43

Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide erythromycylamine

Summary for 2O43

• Entry DOI: 10.2210/pdb2o43/pdb
• Related: 2O44 2O45
• Descriptor: 23S rRNA, (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-AMINO-6-{[(2S,3R,4S,6R)-4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PY RAN-2-YL]OXY}-14-ETHYL-7,12,13-TRIHYDROXY-4-{[(2R,4R,5S,6S)-5-HYDROXY-4-METHOXY-4,6-DIMETHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY }-3,5,7,9,11,13-HEXAMETHYLOXACYCLOTETRADECAN-2-ONE (2 entities in total)
• Functional Keywords: ribosome, macrolides, rna
• Biological source: Deinococcus radiodurans
• Total number of polymer chains: 1
• Total formula weight: 934139.96

Authors

Pyetan, E.,Baram, D.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2006-12-03, release date: 2007-12-04, Last modification date: 2023-08-30)

• Primary citation: Pyetan, E.,Baram, D.,Auerbach-Nevo, T.,Yonath, A.; Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (3.6 Å)