2O45

Structure of the 23S rRNA of the large ribosomal subunit from Deinococcus Radiodurans in complex with the macrolide RU-69874

Summary for 2O45

• Entry DOI: 10.2210/pdb2o45/pdb
• Related: 2O43 2O44
• Descriptor: 23S rRNA, (3AS,4R,7R,8S,9S,10R,11R,13R,15R,15AR)-4-ETHYL-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-2,6,14-TRIOXO-1-[4-(4-PYRIDIN-3-YL-1H-IMIDAZOL-1-YL)BUTYL]-10-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}TETRADECAHYDRO-2H-OXACYCLOTETRADECINO[4,3-D][1,3]OXAZOL-8-YL 2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE (2 entities in total)
• Functional Keywords: ribosome, macrolides, tunnel, rna
• Biological source: Deinococcus radiodurans
• Total number of polymer chains: 1
• Total formula weight: 934377.21

Authors

Baram, D.,Pyetan, E.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2006-12-03, release date: 2007-12-04, Last modification date: 2023-08-30)

• Primary citation: Baram, D.,Pyetan, E.,Auerbach-Nevo, T.,Yonath, A.; Chemical Parameters Influencing Fine Tuning in the Binding of Macrolide Antibiotics to the Ribosomal Tunnel; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (3.6 Å)