7ELW

Crystal structure of RNase L in complex with Myricetin

Summary for 7ELW

• Entry DOI: 10.2210/pdb7elw/pdb
• Descriptor: Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (4 entities in total)
• Functional Keywords: rnase l, inhibitor, myricetin, hydrolase
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 2
• Total formula weight: 165718.30

Authors

Tang, J.,Huang, H. (deposition date: 2021-04-12, release date: 2021-11-24, Last modification date: 2023-11-29)

• Primary citation: Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H.; Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery; J.Med.Chem., 65:1445-1457, 2022; DOI: 10.1021/acs.jmedchem.1c01156

Experimental method

X-RAY DIFFRACTION (3.55 Å)