2O44

Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide josamycin

Summary for 2O44

Related2O43 2O45
Descriptor23S rRNA, (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10S,12E,14Z,16R)-4-(ACETYLOXY)-10-HYDROXY-5-METHOXY-9,16-DIMETHYL-2-OXO-7-(2-OXOETHYL)OXACYCLOHEXADECA-12,14-DIEN-6-YL]OXY}-4-(DIMETHYLAMINO)-5-HYDROXY-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL]OXY}-4-HYDROXY-2,4-DIMETHYLTETRAHYDRO-2H-PYRAN-3-YL 3-METHYLBUTANOATE (2 entities in total)
Functional Keywordsribosome, macrolides, rna
Biological sourceDeinococcus radiodurans
Total number of polymer chains1
Total molecular weight934233
Authors
Pyetan, E.,Daram, D.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2006-12-03, release date: 2007-12-04, Last modification date: 2011-12-28)
Primary citation
Pyetan, E.,Baram, D.,Auerbach-Nevo, T.,Yonath, A.
Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel
TO BE PUBLISHED,
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

ClashscoreRNA backbone500.42MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2o44
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Molmil generated image of 2o44
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Molmil generated image of 2o44
rotated about y axis by 90°