1I4D
 
 | | CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21) | | Descriptor: | ARFAPTIN 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Tarricone, C, Xiao, B, Justin, N, Gamblin, S.J, Smerdon, S.J. | | Deposit date: | 2001-02-20 | | Release date: | 2001-05-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Nature, 411, 2001
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1KI1
 | | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | | Descriptor: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | | Authors: | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | | Deposit date: | 2001-12-02 | | Release date: | 2002-05-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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1KMQ
 | | Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L) | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Longenecker, K, Read, P, Lin, S.-K, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. | | Deposit date: | 2001-12-17 | | Release date: | 2003-05-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
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1MQE
 | | Structure of the MT-ADPRase in complex with gadolidium and ADP-ribose, a Nudix enzyme | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, ADPR pyrophosphatase, GADOLINIUM ION | | Authors: | Kang, L.-W, Gabelli, S.B, Bianchet, M.A, Cunningham, J.E, O'Handley, S.F, Amzel, L.M. | | Deposit date: | 2002-09-16 | | Release date: | 2003-08-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and mechanism of MT-ADPRase, a Nudix hydrolase from Mycobacterium tuberculosis
Structure, 11, 2003
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9B4H
 | | Chlamydomonas reinhardtii mastigoneme filament | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain-containing protein, Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein, ... | | Authors: | Dai, J, Ma, M, Zhang, R, Brown, A. | | Deposit date: | 2024-03-20 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices.
Cell, 2024
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1LB1
 | | Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA | | Descriptor: | Guanine nucleotide exchange factor DBS, Transforming protein RhoA | | Authors: | Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. | | Deposit date: | 2002-04-01 | | Release date: | 2002-05-29 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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1XQZ
 | | Crystal Structure of hPim-1 kinase at 2.1 A resolution | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Qian, K.C, Wang, L, Hickey, E.R, Studts, J, Barringer, K, Peng, C, Kronkaitis, A, Li, J, White, A, Mische, S, Farmer, B. | | Deposit date: | 2004-10-13 | | Release date: | 2004-11-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase.
J.Biol.Chem., 280, 2005
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1QO1
 | | Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria | | Descriptor: | ATP SYNTHASE ALPHA CHAIN, ATP SYNTHASE BETA CHAIN, ATP SYNTHASE DELTA CHAIN, ... | | Authors: | Stock, D, Leslie, A.G.W, Walker, J.E. | | Deposit date: | 1999-11-01 | | Release date: | 1999-11-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Molecular Architecture of the Rotary Motor in ATP Synthase
Science, 286, 1999
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1LCI
 | | FIREFLY LUCIFERASE | | Descriptor: | LUCIFERASE | | Authors: | Conti, E, Franks, N.P, Brick, P. | | Deposit date: | 1996-06-01 | | Release date: | 1997-03-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.
Structure, 4, 1996
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2QOI
 | | Human EphA3 kinase and juxtamembrane region, Y596F:Y602F double mutant | | Descriptor: | BETA-MERCAPTOETHANOL, Ephrin receptor | | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-07-20 | | Release date: | 2007-08-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3).
Structure, 16, 2008
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8TV8
 | | Crystal structure of nontypeable Haemophilus influenzae SapA | | Descriptor: | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance | | Authors: | Tanaka, K.J, Buechel, E.R, Rivera, K.G, Pinkett, H.W. | | Deposit date: | 2023-08-17 | | Release date: | 2024-01-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Antimicrobial Peptide Recognition Motif of the Substrate Binding Protein SapA from Nontypeable Haemophilus influenzae .
Biochemistry, 63, 2024
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2QOL
 | | Human EphA3 kinase and juxtamembrane region, Y596:Y602:S768G triple mutant | | Descriptor: | Ephrin receptor | | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-07-20 | | Release date: | 2007-08-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3).
Structure, 16, 2008
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4WYZ
 | | The crystal structure of the A109G mutant of RNase A in complex with 3'UMP | | Descriptor: | 3'-URIDINEMONOPHOSPHATE, Ribonuclease pancreatic | | Authors: | French, R.L, Gagne, D, Doucet, N, Simonovic, M. | | Deposit date: | 2014-11-18 | | Release date: | 2015-11-18 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.449 Å) | | Cite: | Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity.
Structure, 23, 2015
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5FOC
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21) | | Descriptor: | LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FOF
 | | Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain | | Descriptor: | LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FOD
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3 | | Descriptor: | 1,2-ETHANEDIOL, LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FO4
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) | | Descriptor: | LEUCYL TRNA SYNTHASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-18 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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2H7V
 | | Co-crystal structure of YpkA-Rac1 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Migration-inducing protein 5, ... | | Authors: | Prehna, G, Ivanov, M, Bliska, J.B, Stebbins, C.E. | | Deposit date: | 2006-06-04 | | Release date: | 2006-09-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors.
Cell(Cambridge,Mass.), 126, 2006
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2HBR
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2HBZ
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2HBY
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5FON
 | | Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure) | | Descriptor: | LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S. | | Deposit date: | 2015-11-24 | | Release date: | 2016-08-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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2IX8
 | | MODEL FOR EEF3 BOUND TO AN 80S RIBOSOME | | Descriptor: | ELONGATION FACTOR 3A | | Authors: | Andersen, C.B.F, Becker, T, Blau, M, Anand, M, Halic, M, Balar, B, Mielke, T, Boesen, T, Pedersen, J.S, Spahn, C.M.T, Kinzy, T.G, Andersen, G.R, Beckmann, R. | | Deposit date: | 2006-07-07 | | Release date: | 2007-07-10 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Structure of Eef3 and the Mechanism of Transfer RNA Release from the E-Site.
Nature, 443, 2006
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2CB8
 | | High resolution crystal structure of liganded human L-ACBP | | Descriptor: | 2-METHOXYETHANOL, ACYL-COA-BINDING PROTEIN, SULFATE ION, ... | | Authors: | Taskinen, J.P, van Aalten, D.M, Knudsen, J, Wierenga, R.K. | | Deposit date: | 2006-01-03 | | Release date: | 2006-10-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | High Resolution Crystal Structures of Unliganded and Liganded Human Liver Acbp Reveal a New Mode of Binding for the Acyl-Coa Ligand.
Proteins: Struct., Funct., Bioinf., 66, 2007
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2D5D
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