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2HBR

Crystal structure of human caspase-1 (Arg286->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

Replaces:  2FQS
Summary for 2HBR
Entry DOI10.2210/pdb2hbr/pdb
Related1SC1 1SC3 1SC4 2FQQ 2HBQ 2HBY 2HBZ
Related PRD IDPRD_000338
DescriptorCaspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide, ... (4 entities in total)
Functional Keywordsactive-site inhibitor, allosteric circuit, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm: P29466 P29466
Total number of polymer chains3
Total formula weight30514.39
Authors
Scheer, J.M.,Wells, J.A.,Romanowski, M.J. (deposition date: 2006-06-14, release date: 2006-06-27, Last modification date: 2023-08-30)
Primary citationScheer, J.M.,Romanowski, M.J.,Wells, J.A.
A Common Allosteric Site and Mechanism in Caspases
Proc.Natl.Acad.Sci.USA, 103:7595-7600, 2006
Cited by
PubMed: 16682620
DOI: 10.1073/pnas.0602571103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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