PDB: 5425 resultsInfo pagesStatus searchChemie searchBIRD

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4O72	Crystal structure of the first bromodomain of human BRD4 in complex with NU7441 Descriptor: 1,2-ETHANEDIOL, 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one, Bromodomain-containing protein 4, ... Authors: Zhu, J.-Y, Ember, S.W, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
4O7A	Crystal structure of the first bromodomain of human BRD4 in complex with SB-409514 Descriptor: 1,2-ETHANEDIOL, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophenyl)-1H-pyrrole-2,5-dione, Bromodomain-containing protein 4 Authors: Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
4O7C	Crystal structure of the first bromodomain of human BRD4 in complex with SB-614067-R Descriptor: 1,2-ETHANEDIOL, 4-[(5Z)-5-(1-nitroso-2,3-dihydro-5H-inden-5-ylidene)-2-(piperidin-4-yl)-3,5-dihydro-4H-imidazol-4-ylidene]-1,4-dihydropyridine, Bromodomain-containing protein 4 Authors: Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
4O74	Crystal structure of the first bromodomain of human BRD4 in complex with BI 2536 Descriptor: 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4, ... Authors: Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
4O7E	Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B Descriptor: 1,2-ETHANEDIOL, 3-[2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl]phenol, Bromodomain-containing protein 4 Authors: Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
4OGI	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536 Descriptor: 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4 Authors: Filippakopoulos, P, Picaud, S, Jose, B, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2014-01-16 Release date: 2014-02-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat.Chem.Biol., 10, 2014
4OJN	Crystal structure of human muscle L-lactate dehydrogenase Descriptor: GLYCEROL, L-lactate dehydrogenase A chain, PENTAETHYLENE GLYCOL Authors: Kolappan, S, Craig, L. Deposit date: 2014-01-21 Release date: 2014-12-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
8QPK	Cryo-EM Structure of Pre-B+5'ss Complex (core part) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-02 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8QOZ	Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-09-29 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8R0A	Cryo-EM structure of the cross-exon pre-B+5'ss complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8QPB	Cryo-EM Structure of Pre-B+ATP Complex (core part) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-01 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8QZS	Cryo-EM structure of the cross-exon B-like complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-29 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8QPA	Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-01 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8R0B	Cryo-EM structure of the cross-exon pre-B+ATP complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8QO9	Cryo-EM structure of a human spliceosomal B complex protomer Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. Deposit date: 2023-09-28 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (5.29 Å) Cite: New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
8Q7N	cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. Deposit date: 2023-08-16 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
8E9F	WD repeat-containing protein 5 complexed with 4-(7-((1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-ethyl-N-methylquinoline-8-carboxamide (compound 10) Descriptor: 6-ethyl-4-[(5P)-7-[(1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl]-N-methylquinoline-8-carboxamide, BENZAMIDINE, WD repeat-containing protein 5 Authors: Rietz, T.A, Fesik, S.W. Deposit date: 2022-08-26 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proc.Natl.Acad.Sci.USA, 120, 2023
8E3D	ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11) Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*AP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*AP*T)-3'), ... Authors: Horton, J.R, Ren, R, Cheng, X. Deposit date: 2022-08-17 Release date: 2023-02-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
8E3E	ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10) Descriptor: DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3'), ZINC ION, ... Authors: Horton, J.R, Ren, R, Cheng, X. Deposit date: 2022-08-17 Release date: 2023-02-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
8E17	BRD4-D1 in complex with BET inhibitor Descriptor: (4P,6M)-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-4-[5-(methanesulfonyl)-2-methoxyphenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. Deposit date: 2022-08-09 Release date: 2023-03-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
8E3W	BRD4-D1 in complex with BET inhibitor Descriptor: (4P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. Deposit date: 2022-08-17 Release date: 2023-03-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
8DYR	BRD4-D1 in complex with BET inhibitor Descriptor: (4P,6P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. Deposit date: 2022-08-04 Release date: 2023-03-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
8E84	Human PCNA mutant- C148S Descriptor: Proliferating cell nuclear antigen Authors: Magrino, J, Page, B, Gaubitz, C, Kelch, B.A. Deposit date: 2022-08-25 Release date: 2023-04-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder. J.Biol.Chem., 299, 2023
8E67	ETV6 H396Y variant bound to DNA containing the sequence GGAT Descriptor: Complementary 15 bp strand, GGAT-containing 15 bp DNA, Transcription factor ETV6 Authors: Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. Deposit date: 2022-08-22 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The functional role of histidine within the ETV6 ETS domain to be published
8E66	ETV6 H396Y variant bound to DNA containing the sequence GGAA Descriptor: CACODYLATE ION, Complementary 15 bp strand, GGAA-containing 15 bp DNA, ... Authors: Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. Deposit date: 2022-08-22 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The functional role of histidine within the ETV6 ETS domain to be published

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