PDB: 113 resultsInfo pagesStatus searchChemie searchBIRD

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8GQ5	Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Descriptor: NAD(+) hydrolase SARM1, Nanobody C6 Authors: Cai, Y, Zhang, H. Deposit date: 2022-08-29 Release date: 2023-01-18 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022
8BW9	Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP Descriptor: Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... Authors: Maisonneuve, P, Fronzes, R, Sicheri, F. Deposit date: 2022-12-06 Release date: 2024-02-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 2024
8BW8	Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex Descriptor: Connector enhancer of KSR protein CNK, GLYCEROL, Protein aveugle Authors: Maisonneuve, P, Kurinov, I, Sicheri, F. Deposit date: 2022-12-06 Release date: 2024-02-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 2024
8P2M	C. elegans TIR-1 protein. Descriptor: NAD(+) hydrolase tir-1 Authors: Isupov, M.N, Opatowsky, Y. Deposit date: 2023-05-16 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.82 Å) Cite: Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Rep, 42, 2023
8P2L	A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain. Descriptor: NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Isupov, M.N, Opatowsky, Y. Deposit date: 2023-05-16 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Rep, 42, 2023
8TDW	ssRNA bound SAMHD1 T open Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ... Authors: Sung, M, Huynh, K, Han, S. Deposit date: 2023-07-05 Release date: 2023-11-22 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
8TDV	ssRNA bound SAMHD1 T closed Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ... Authors: Sung, M, Huynh, K, Han, S. Deposit date: 2023-07-05 Release date: 2023-12-20 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
8QXM	Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
8QXN	Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
8QXJ	Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.65 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
8QXL	Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
8QXK	Cryo-EM structure of tetrameric human SAMHD1 State I - Tense Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
8QXO	Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... Authors: Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. Deposit date: 2023-10-24 Release date: 2024-05-15 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024

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