PDB: 11971 resultsInfo pagesStatus searchChemie searchBIRD

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6TEL	Crystal structure of Dot1L in complex with an inhibitor (compound 10). Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, POTASSIUM ION, ... Authors: Scheufler, C, Stauffer, F, Be, C, Moebitz, H. Deposit date: 2019-11-12 Release date: 2019-12-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.19 Å) Cite: New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
6TEN	Crystal structure of Dot1L in complex with an inhibitor (compound 11). Descriptor: 3-[(4-azanyl-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]amino]benzenesulfonamide, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... Authors: Scheufler, C, Stauffer, F, Be, C, Moebitz, H. Deposit date: 2019-11-12 Release date: 2019-12-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.21 Å) Cite: New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
8SVF	BAP1/ASXL1 bound to the H2AK119Ub Nucleosome Descriptor: DNA/RNA (187-MER), DNA/RNA (327-MER), Histone H2A type 1, ... Authors: Thomas, J.F, Valencia-Sanchez, M.I, Armache, K.-J. Deposit date: 2023-05-16 Release date: 2023-08-30 Last modified: 2024-11-27 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1. Sci Adv, 9, 2023
6FML	CryoEM Structure INO80core Nucleosome complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin related protein 5, ... Authors: Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. Deposit date: 2018-01-31 Release date: 2018-04-25 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.34 Å) Cite: Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
8SKZ	Cryo-EM structure of DDM1-HELLS chimera bound to the nucleosome Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1,Lymphoid-specific helicase chimera, BERYLLIUM TRIFLUORIDE ION, ... Authors: Nartey, W, Williams, G.J. Deposit date: 2023-04-20 Release date: 2024-11-20 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM complex of DDM1-HELLS chimera bound to the nucleosome To Be Published
8THU	Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 Descriptor: DNA (145-MER), DNA (146-MER), Histone H2A.Z, ... Authors: Abini-Agbomson, S, Armache, K.-J. Deposit date: 2023-07-18 Release date: 2023-09-06 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Mol.Cell, 83, 2023
8T9F	Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 Descriptor: DNA (122-MER), Histone H2A.Z, Histone H2B 1.1, ... Authors: Abini-Agbomson, S, Armache, K.-J. Deposit date: 2023-06-23 Release date: 2023-09-06 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Mol.Cell, 83, 2023
8T9H	Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 Descriptor: DNA (146-MER), Histone H2A, Histone H2B 1.1, ... Authors: Abini-Agbomson, S, Armache, K.-J. Deposit date: 2023-06-24 Release date: 2023-09-13 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Mol.Cell, 83, 2023
8T3W	Structure of Bre1-nucleosome complex - state2 Descriptor: 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ... Authors: Zhao, F, Hicks, C.W, Wolberger, C. Deposit date: 2023-06-07 Release date: 2023-10-18 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Mechanism of histone H2B monoubiquitination by Bre1. Nat.Struct.Mol.Biol., 30, 2023
8T3Y	Structure of Bre1-nucleosome complex - state1 Descriptor: 601 DNA Strand 1, 601 DNA Strand 2, E3 ubiquitin-protein ligase BRE1, ... Authors: Zhao, F, Hicks, C.W, Wolberger, C. Deposit date: 2023-06-08 Release date: 2023-10-18 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Mechanism of histone H2B monoubiquitination by Bre1. Nat.Struct.Mol.Biol., 30, 2023
8T3T	Structure of Bre1-nucleosome complex - state3 Descriptor: 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ... Authors: Zhao, F, Hicks, C.W, Wolberger, C. Deposit date: 2023-06-07 Release date: 2023-10-18 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Mechanism of histone H2B monoubiquitination by Bre1. Nat.Struct.Mol.Biol., 30, 2023
6D07	Crystal structure of the complex between human chromobox homolog 1 (CBX1) and H3K9me3 peptide Descriptor: Chromobox protein homolog 1, GLYCEROL, Histone H3.1 Authors: Arora, S, Horne, W.S, Islam, K. Deposit date: 2018-04-10 Release date: 2019-04-10 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions. J.Am.Chem.Soc., 141, 2019
6W5I	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) Descriptor: DNA (147-MER), Histone H2A, Histone H2B 1.1, ... Authors: Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. Deposit date: 2020-03-13 Release date: 2021-03-31 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (6.9 Å) Cite: Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) Descriptor: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. Deposit date: 2020-03-13 Release date: 2021-03-31 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (6 Å) Cite: Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) Descriptor: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. Deposit date: 2020-03-13 Release date: 2021-03-31 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
3X1T	Crystal structure of nucleosome core particle consisting of mouse testis specific histone variants H2aa and H2ba Descriptor: CHLORIDE ION, DNA (146-MER), Histone H2A, ... Authors: Sivaraman, P, Kumarevel, T.S. Deposit date: 2014-11-27 Release date: 2015-09-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.808 Å) Cite: Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming Biochem.Biophys.Res.Commun., 464, 2015
2CV5	Crystal structure of human nucleosome core particle Descriptor: CHLORIDE ION, DNA (146-MER), Histone H2A.a, ... Authors: Tsunaka, Y, Kajimura, N, Tate, S, Morikawa, K. Deposit date: 2005-05-31 Release date: 2005-06-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle Nucleic Acids Res., 33, 2005
9MVY	Crystal structure of ZMET2 in complex with unmethylated CTG DNA and a histone H3Kc9me2 peptide Descriptor: C49 ssDNA, DNA (cytosine-5)-methyltransferase 1, Histone H3.2, ... Authors: Herle, G, Fang, J, Song, J. Deposit date: 2025-01-16 Release date: 2025-05-21 Last modified: 2025-05-28 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structure of an Unfavorable de Novo DNA Methylation Complex of Plant Methyltransferase ZMET2. J.Mol.Biol., 437, 2025
9N6K	2.88 A S.cerevisiae Chd1[L886G/L889G/L891G]-nucleosome 2:1 complex with DNA-binding domain Descriptor: Chromo domain-containing protein 1, DNA Lagging Strand, DNA Tracking Strand, ... Authors: Nodelman, I.M, Folkwein, H.J, Armache, J.-P, Bowman, G.D. Deposit date: 2025-02-05 Release date: 2025-06-11 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA. Nat.Struct.Mol.Biol., 2025
9N6H	2.54 A S.cerevisiae Chd1[L886G/L889G/L891G]-nucleosome 1:1 complex Descriptor: Chromo domain-containing protein 1, DNA Lagging Strand, DNA Tracking Strand, ... Authors: Nodelman, I.M, Folkwein, H.J, Armache, J.-P, Bowman, G.D. Deposit date: 2025-02-05 Release date: 2025-06-11 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA. Nat.Struct.Mol.Biol., 2025
9N6I	2.61 A S.cerevisiae Chd1[L886G/L889G/L891G]-nucleosome 2:1 complex Descriptor: Chromo domain-containing protein 1, DNA Lagging Strand, DNA Tracking Strand, ... Authors: Nodelman, I.M, Folkwein, H.J, Armache, J.-P, Bowman, G.D. Deposit date: 2025-02-05 Release date: 2025-06-11 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA. Nat.Struct.Mol.Biol., 2025
8G6Q	H2AK119ub-modified nucleosome ubiquitin position 1 Descriptor: 601 DNA (147-MER), Histone H2A, Histone H2B 1.1, ... Authors: Hicks, C.W, Wolberger, C, Keogh, M. Deposit date: 2023-02-15 Release date: 2024-02-21 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch. Nucleic Acids Res., 52, 2024
8G6S	H2AK119ub-modified nucleosome ubiquitin position 2 Descriptor: 601 DNA (147-MER), Histone H2A, Histone H2B 1.1, ... Authors: Hicks, C.W, Wolberger, C, Keogh, M. Deposit date: 2023-02-15 Release date: 2024-02-21 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch. Nucleic Acids Res., 52, 2024
8X2Z	The class2 of piccolo NuA4 bound to the H2A.Z nucleosome complex at harboring state Descriptor: Chromatin modification-related protein, DNA (146-MER), Histone H2A, ... Authors: Wang, L, Zhang, H, Zhu, H, Zhu, P. Deposit date: 2023-11-10 Release date: 2025-03-19 Last modified: 2025-04-02 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structures reveal the acetylation process of piccolo NuA4. Proc.Natl.Acad.Sci.USA, 122, 2025
8X32	The piccolo NuA4 bound to the H2A.Z nucleosome-H4KQ Complex with Ac-CoA at resetting state Descriptor: Chromatin modification-related protein, DNA (146-MER), Histone H2A, ... Authors: Wang, L, Zhang, H, Zhu, H, Zhu, P. Deposit date: 2023-11-10 Release date: 2025-03-19 Last modified: 2025-04-02 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Cryo-EM structures reveal the acetylation process of piccolo NuA4. Proc.Natl.Acad.Sci.USA, 122, 2025

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