6TEN

Crystal structure of Dot1L in complex with an inhibitor (compound 11).

Summary for 6TEN

Entry DOI	10.2210/pdb6ten/pdb
Related	6TE6 6TEL
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-79 specific, 3-[(4-azanyl-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]amino]benzenesulfonamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	dot1l, complex structure, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	78387.30
Authors	Scheufler, C.,Stauffer, F.,Be, C.,Moebitz, H. (deposition date: 2019-11-12, release date: 2019-12-11, Last modification date: 2024-01-24)
Primary citation	Stauffer, F.,Weiss, A.,Scheufler, C.,Mobitz, H.,Ragot, C.,Beyer, K.S.,Calkins, K.,Guthy, D.,Kiffe, M.,Van Eerdenbrugh, B.,Tiedt, R.,Gaul, C. New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10:1655-1660, 2019 Cited by PubMed: 31857842 DOI: 10.1021/acsmedchemlett.9b00452 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation