6TEL
Crystal structure of Dot1L in complex with an inhibitor (compound 10).
Summary for 6TEL
Entry DOI | 10.2210/pdb6tel/pdb |
Related | 6TE6 |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, ~{N}1-[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]-~{N}2-(4-methoxy-6-piperazin-1-yl-1,3,5-triazin-2-yl)-4-methylsulfonyl-benzene-1,2-diamine, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | dot1l, complex structure, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 78274.44 |
Authors | Scheufler, C.,Stauffer, F.,Be, C.,Moebitz, H. (deposition date: 2019-11-12, release date: 2019-12-11, Last modification date: 2024-01-24) |
Primary citation | Stauffer, F.,Weiss, A.,Scheufler, C.,Mobitz, H.,Ragot, C.,Beyer, K.S.,Calkins, K.,Guthy, D.,Kiffe, M.,Van Eerdenbrugh, B.,Tiedt, R.,Gaul, C. New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10:1655-1660, 2019 Cited by PubMed: 31857842DOI: 10.1021/acsmedchemlett.9b00452 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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