4MHL
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![BU of 4mhl by Molmil](/molmil-images/mine/4mhl) | The crystal structure of human interleukin-11 | Descriptor: | FORMAMIDE, Interleukin-11, SULFATE ION | Authors: | Griffin, M.D.W. | Deposit date: | 2013-08-29 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. Acta Crystallogr.,Sect.D, 70, 2014
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4MHR
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![BU of 4mhr by Molmil](/molmil-images/mine/4mhr) | Crystal structure of EctD from S. alaskensis in its apoform | Descriptor: | Ectoine hydroxylase | Authors: | Widderich, N, Hoeppner, A, Pittelkow, M, Heider, J, Smits, S.H, Bremer, E. | Deposit date: | 2013-08-30 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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6ZHC
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![BU of 6zhc by Molmil](/molmil-images/mine/6zhc) | PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL | Descriptor: | 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... | Authors: | Chung, C. | Deposit date: | 2020-06-22 | Release date: | 2020-08-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
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4FQX
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![BU of 4fqx by Molmil](/molmil-images/mine/4fqx) | Crystal structure of HLA-DM bound to HLA-DR1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DM alpha chain, ... | Authors: | Sethi, D.K, Pos, W, Wucherpfennig, K.W. | Deposit date: | 2012-06-25 | Release date: | 2013-01-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.599 Å) | Cite: | Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection. Cell(Cambridge,Mass.), 151, 2012
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6ZI4
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![BU of 6zi4 by Molmil](/molmil-images/mine/6zi4) | Ultrafast Structural Response to Charge Redistribution Within a Photosynthetic Reaction Centre - 5 ps (a) structure | Descriptor: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | Authors: | Baath, P, Dods, R, Braenden, G, Neutze, R. | Deposit date: | 2020-06-24 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ultrafast structural changes within a photosynthetic reaction centre. Nature, 589, 2021
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3GF4
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![BU of 3gf4 by Molmil](/molmil-images/mine/3gf4) | Structure of UDP-galactopyranose mutase bound to UDP-glucose | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, UDP-galactopyranose mutase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, ... | Authors: | Gruber, T.D, Borrok, M.J, Kiessling, L.L, Forest, K.T. | Deposit date: | 2009-02-26 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Ligand binding and substrate discrimination by UDP-galactopyranose mutase. J.Mol.Biol., 391, 2009
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4M7E
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![BU of 4m7e by Molmil](/molmil-images/mine/4m7e) | Structural insight into BL-induced activation of the BRI1-BAK1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1, ... | Authors: | Chai, J, Han, Z, Sun, Y. | Deposit date: | 2013-08-12 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.602 Å) | Cite: | Structural insight into BL-induced activation of the BRI1-BAK1 complex To be Published
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6ZJL
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![BU of 6zjl by Molmil](/molmil-images/mine/6zjl) | Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ... | Authors: | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | Deposit date: | 2020-06-29 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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6ZIY
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![BU of 6ziy by Molmil](/molmil-images/mine/6ziy) | Respiratory complex I from Thermus thermophilus, NADH dataset, major state | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | Authors: | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | Deposit date: | 2020-06-26 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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4H0T
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![BU of 4h0t by Molmil](/molmil-images/mine/4h0t) | Crystal structure of Ia-ADPR-actin complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Tsurumura, T, Oda, M, Nagahama, M, Tsuge, H. | Deposit date: | 2012-09-10 | Release date: | 2013-02-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex Proc.Natl.Acad.Sci.USA, 110, 2013
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6ZK0
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![BU of 6zk0 by Molmil](/molmil-images/mine/6zk0) | 1.47A human IMPase with ebselen | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Inositol monophosphatase 1, ... | Authors: | Bax, B.D, Fenn, G.D. | Deposit date: | 2020-06-29 | Release date: | 2020-09-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase. Acta Crystallogr.,Sect.F, 76, 2020
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6Z0O
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![BU of 6z0o by Molmil](/molmil-images/mine/6z0o) | Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein | Descriptor: | Affimer-NP, Nucleocapsid | Authors: | Alvarez-Rodriguez, B, Tiede, C, Trinh, C, Tomlinson, D, Edwards, T.A, Barr, J.N. | Deposit date: | 2020-05-10 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5974 Å) | Cite: | Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests. Plos Negl Trop Dis, 14, 2020
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4H2M
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![BU of 4h2m by Molmil](/molmil-images/mine/4h2m) | Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408 | Descriptor: | 2,2'-{benzene-1,3-diylbis[ethyne-2,1-diyl(5-bromobenzene-3,1-diyl)]}diethanamine, Undecaprenyl pyrophosphate synthase | Authors: | Zhu, W, Oldfield, E. | Deposit date: | 2012-09-12 | Release date: | 2012-12-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
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3GIC
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![BU of 3gic by Molmil](/molmil-images/mine/3gic) | Structure of thrombin mutant delta(146-149e) in the free form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | Authors: | Bah, A, Carrell, C.J, Chen, Z, Gandhi, P.S, Di Cera, E. | Deposit date: | 2009-03-05 | Release date: | 2009-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Stabilization of the E* form turns thrombin into an anticoagulant. J.Biol.Chem., 284, 2009
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6Z1J
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![BU of 6z1j by Molmil](/molmil-images/mine/6z1j) | Photosynthetic Reaction Center From Rhodobacter Sphaeroides strain RV LSP co-crystallization with spheroidene | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, BACTERIOCHLOROPHYLL A, ... | Authors: | Gabdulkhakov, A.G, Fufina, T.Y, Vasilieva, L.G, Betzel, C, Selikhanov, G.K. | Deposit date: | 2020-05-13 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Novel approaches for the lipid sponge phase crystallization of the Rhodobacter sphaeroides photosynthetic reaction center. Iucrj, 7, 2020
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6YSU
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![BU of 6ysu by Molmil](/molmil-images/mine/6ysu) | Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V. | Deposit date: | 2020-04-23 | Release date: | 2020-08-19 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanism of ribosome rescue by alternative ribosome-rescue factor B. Nat Commun, 11, 2020
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4H5O
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4HAQ
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![BU of 4haq by Molmil](/molmil-images/mine/4haq) | Crystal Structure of a GH7 family cellobiohydrolase from Limnoria quadripunctata in complex with cellobiose and cellotriose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GH7 family protein, ... | Authors: | Martin, R.N.A, McGeehan, J.E, Streeter, S.D, Cragg, S.M, Guille, M.J, Schnorr, K.M, Kern, M, Bruce, N.C, McQueen-Mason, S.J. | Deposit date: | 2012-09-27 | Release date: | 2013-06-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance Proc.Natl.Acad.Sci.USA, 110, 2013
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4HCC
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![BU of 4hcc by Molmil](/molmil-images/mine/4hcc) | The zinc ion bound form of crystal structure of E.coli ExoI-ssDNA complex | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), Exodeoxyribonuclease I, ISOPROPYL ALCOHOL, ... | Authors: | Qiu, R, Wei, J, Lou, T, Liu, M, Ji, C, Gong, W. | Deposit date: | 2012-09-29 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | The structures of Escherichia coli exonuclease I in complex with the single strand DNA To be published
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3JZM
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![BU of 3jzm by Molmil](/molmil-images/mine/3jzm) | Crystal structure of the phosphorylation-site mutant T432A of the KaiC circadian clock protein | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase kaiC, MAGNESIUM ION | Authors: | Pattanayek, R, Egli, M, Pattanayek, S. | Deposit date: | 2009-09-23 | Release date: | 2010-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase. Plos One, 4, 2009
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7LPS
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![BU of 7lps by Molmil](/molmil-images/mine/7lps) | Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2) | Descriptor: | 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Nowak, R.P, Fischer, E.S. | Deposit date: | 2021-02-12 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.78 Å) | Cite: | Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol., 17, 2021
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6Z3Z
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3J8K
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![BU of 3j8k by Molmil](/molmil-images/mine/3j8k) | Tilted state of actin, T2 | Descriptor: | Actin, alpha skeletal muscle | Authors: | Galkin, V.E, Orlova, A, Vos, M.R, Schroder, G.F, Egelman, E.H. | Deposit date: | 2014-11-07 | Release date: | 2015-01-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (12 Å) | Cite: | Near-atomic resolution for one state of f-actin. Structure, 23, 2015
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4GQE
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![BU of 4gqe by Molmil](/molmil-images/mine/4gqe) | Structure of rat neuronal nitric oxide synthase heme domain in complex with (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline | Descriptor: | (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2012-08-22 | Release date: | 2013-05-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction Biochemistry, 52, 2013
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3K5C
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![BU of 3k5c by Molmil](/molmil-images/mine/3k5c) | Human BACE-1 complex with NB-216 | Descriptor: | (4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phenyl]cyclopropyl}amino)ethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1~6,10~]docosa-1(21),6(22),7,9,17,19-hexaen-2-one, Beta-secretase 1 | Authors: | Rondeau, J.-M. | Deposit date: | 2009-10-07 | Release date: | 2010-03-02 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg.Med.Chem.Lett., 20, 2010
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