PDB: 5591 resultsInfo pagesStatus searchChemie searchBIRD

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2QCG	Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-bromo-UMP Descriptor: 5-BROMO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase (UMP synthase) Authors: Wittmann, J, Rudolph, M. Deposit date: 2007-06-19 Release date: 2007-11-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16, 2008
2QCH	Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-iodo-UMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-IODO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, IODIDE ION, ... Authors: Wittmann, J, Rudolph, M. Deposit date: 2007-06-19 Release date: 2007-11-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16, 2008
2Q8Z	Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase complexed with 6-amino-UMP Descriptor: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 6-AMINOURIDINE 5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... Authors: Liu, Y, Lau, W, Bello, A.M, Kotra, L.P, Hui, R, Pai, E.F. Deposit date: 2007-06-12 Release date: 2008-01-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase. J.Med.Chem., 51, 2008
2PTQ	Crystal structure of Escherichia coli adenylosuccinate lyase mutant H171N with bound AMP and fumarate Descriptor: ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, FUMARIC ACID Authors: Tsai, M, Howell, P.L. Deposit date: 2007-05-08 Release date: 2007-07-03 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism. J.Mol.Biol., 370, 2007
3C3N	Crystal structure of dihydroorotate dehydrogenase from Trypanosoma cruzi strain Y Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... Authors: Pinheiro, M.P, Iulek, J, Nonato, M.C. Deposit date: 2008-01-28 Release date: 2008-04-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain Biochem.Biophys.Res.Commun., 369, 2008
2QCD	Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP Descriptor: URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase (UMP synthase) Authors: Wittmann, J, Rudolph, M. Deposit date: 2007-06-19 Release date: 2007-11-06 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16, 2008
2FPV	Dual binding mode of a novel series of DHODH inhibitors Descriptor: 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... Authors: Baumgartner, R, Leban, J. Deposit date: 2006-01-17 Release date: 2007-01-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FPT	Dual Binding Mode of a Novel Series of DHODH inhibitors Descriptor: 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... Authors: Baumgartner, R, Walloschek, M, Kralik, M, Gotschlich, A, Tasler, S, Leban, J. Deposit date: 2006-01-17 Release date: 2007-01-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FPY	Dual binding mode of a novel series of DHODH inhibitors Descriptor: 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... Authors: Baumgartner, R, Leban, J. Deposit date: 2006-01-17 Release date: 2007-01-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FQI	dual binding modes of a novel series of DHODH inhibitors Descriptor: 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... Authors: Baumgartner, R, Leban, J. Deposit date: 2006-01-18 Release date: 2007-01-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
7LVP	Cryptococcus neoformans AIR synthetase Descriptor: 1,2-ETHANEDIOL, AIR synthase, GLYCINE, ... Authors: Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A. Deposit date: 2021-02-26 Release date: 2021-08-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. J.Biol.Chem., 297, 2021
7LVO	Cryptococcus neoformans GAR synthetase Descriptor: 1,2-ETHANEDIOL, phosphoribosyl-glycinamide (GAR) synthetase Authors: Chua, S.M.H, Luo, Z, Lim, B.Y.J, Kobe, B, Fraser, J.A. Deposit date: 2021-02-26 Release date: 2021-08-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. J.Biol.Chem., 297, 2021
6MQ2	De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-2 Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, mini-eVgL membrane protein Authors: Mravic, M, Liu, L, Degrado, W.F. Deposit date: 2018-10-09 Release date: 2019-04-03 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Packing of apolar side chains enables accurate design of highly stable membrane proteins. Science, 363, 2019
6MPW	De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-1 Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, mini-eVgL membrane protein Authors: Mravic, M, Liu, L, DeGrado, W.F. Deposit date: 2018-10-08 Release date: 2019-04-03 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Packing of apolar side chains enables accurate design of highly stable membrane proteins. Science, 363, 2019
1DOR	DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS Descriptor: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE Authors: Rowland, P, Larsen, S. Deposit date: 1997-01-14 Release date: 1997-04-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis. Structure, 5, 1997
1F76	ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE Descriptor: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ... Authors: Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S. Deposit date: 2000-06-26 Release date: 2002-10-16 Last modified: 2014-03-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases Structure, 10, 2002
6VFJ	De novo designed icosahedral nanoparticle I53_dn5 Descriptor: I53_dn5A, I53_dn5B Authors: Antanasijevic, A, Ward, A.B. Deposit date: 2020-01-05 Release date: 2020-08-12 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (5.35 Å) Cite: Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. Elife, 9, 2020
6VFI	De novo designed octahedral nanoparticle O43_dn18 Descriptor: O43_dn18A, O43_dn18B Authors: Antanasijevic, A, Ward, A.B. Deposit date: 2020-01-05 Release date: 2020-08-12 Last modified: 2020-08-19 Method: ELECTRON MICROSCOPY (4.54 Å) Cite: Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. Elife, 9, 2020
6FMD	Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold Descriptor: 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ACETATE ION, CHLORIDE ION, ... Authors: Goyal, P, Jarva, M, Andersson, M, Lolli, M.L, Friemann, R. Deposit date: 2018-01-30 Release date: 2018-07-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors. J. Med. Chem., 61, 2018
6J3B	Crystal structure of human DHODH in complex with inhibitor 1289 Descriptor: (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, ACETATE ION, CHLORIDE ION, ... Authors: Yu, Y, Chen, Q. Deposit date: 2019-01-04 Release date: 2019-08-21 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode. Febs Open Bio, 9, 2019
6J3C	Crystal structure of human DHODH in complex with inhibitor 1291 Descriptor: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... Authors: Yu, Y, Chen, Q. Deposit date: 2019-01-04 Release date: 2019-08-21 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.851 Å) Cite: A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode. Febs Open Bio, 9, 2019
6I0O	Structure of human IMP dehydrogenase, isoform 2, bound to GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, SULFATE ION Authors: Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. Deposit date: 2018-10-26 Release date: 2019-01-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.623 Å) Cite: A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
6I0M	Structure of human IMP dehydrogenase, isoform 2, bound to GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... Authors: Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. Deposit date: 2018-10-26 Release date: 2019-01-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.567 Å) Cite: A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
6L0I	Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae Descriptor: (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION Authors: Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. Deposit date: 2019-09-26 Release date: 2020-12-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
6L0F	Crystal structure of dihydroorotase in complex with 5-Aminouracil from Saccharomyces cerevisiae Descriptor: 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, Dihydroorotase, ZINC ION Authors: Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. Deposit date: 2019-09-26 Release date: 2020-12-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.26 Å) Cite: Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021

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