6FMD

Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold

Summary for 6FMD

Entry DOI	10.2210/pdb6fmd/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide, CHLORIDE ION, ... (9 entities in total)
Functional Keywords	dhodh, inhibitor complex, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45637.54
Authors	Goyal, P.,Jarva, M.,Andersson, M.,Lolli, M.L.,Friemann, R. (deposition date: 2018-01-30, release date: 2018-07-11, Last modification date: 2024-01-17)
Primary citation	Sainas, S.,Pippione, A.C.,Lupino, E.,Giorgis, M.,Circosta, P.,Gaidano, V.,Goyal, P.,Bonanni, D.,Rolando, B.,Cignetti, A.,Ducime, A.,Andersson, M.,Jarva, M.,Friemann, R.,Piccinini, M.,Ramondetti, C.,Buccinna, B.,Al-Karadaghi, S.,Boschi, D.,Saglio, G.,Lolli, M.L. Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors. J. Med. Chem., 61:6034-6055, 2018 Cited by PubMed: 29939742 DOI: 10.1021/acs.jmedchem.8b00373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation