6FMD
Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 395 | 42929.2 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | B (A) | 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 401.3 | 1 | Chemie (DUH) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 5 | F, G, H, I, J... (A) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 6 | L (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 7 | M, N, O, P (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | Q, R, S, T, U... (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 6 | Chemie (PGE) | |||
| 9 | W (A) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42929.2 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2708.3 | |
| All* | Total formula weight | 45637.5 |
