2QCG
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-bromo-UMP
Summary for 2QCG
| Entry DOI | 10.2210/pdb2qcg/pdb |
| Related | 2jgy 2qcc 2qcd 2qce 2qcf 2v30 |
| Descriptor | Uridine 5'-monophosphate synthase (UMP synthase), 5-BROMO-URIDINE-5'-MONOPHOSPHATE (3 entities in total) |
| Functional Keywords | ump synthase, decarboxylase, catalytic proficiency, lyase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 57405.64 |
| Authors | Wittmann, J.,Rudolph, M. (deposition date: 2007-06-19, release date: 2007-11-06, Last modification date: 2024-02-21) |
| Primary citation | Wittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16:82-92, 2008 Cited by PubMed: 18184586DOI: 10.1016/j.str.2007.10.020 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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