2HH3
 
 | | Solution structure of the third KH domain of KSRP | | Descriptor: | KH-type splicing regulatory protein | | Authors: | Garcia-Mayoral, M.F. | | Deposit date: | 2006-06-27 | | Release date: | 2007-05-08 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | The Structure of the C-Terminal KH Domains of KSRP Reveals a Noncanonical Motif Important for mRNA Degradation.
Structure, 15, 2007
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2HMP
 | | Uncomplexed actin cleaved with protease ECP32 | | Descriptor: | 1,2-ETHANEDIOL, 2,2',2''-NITRILOTRIETHANOL, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Klenchin, V.A, Khaitlina, S.Y, Rayment, I. | | Deposit date: | 2006-07-11 | | Release date: | 2006-09-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.899 Å) | | Cite: | Crystal structure of polymerization-competent actin
J.Mol.Biol., 362, 2006
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2HIJ
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2HIZ
 | | Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor | | Descriptor: | BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE, Beta-secretase 1, PHOSPHATE ION | | Authors: | Benson, T.E, Prince, D.B, Tomasselli, A.G, Emmons, T.L, Paddock, D.J. | | Deposit date: | 2006-06-29 | | Release date: | 2007-01-23 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design of potent inhibitors of human beta-secretase. Part 1.
Bioorg.Med.Chem.Lett., 17, 2007
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2LS8
 | | Solution structure of human C-type lectin domain family 4 member D | | Descriptor: | C-type lectin domain family 4 member D | | Authors: | Harris, R, Gaudette, J, Bandaranayake, A.D, Banu, R, Bonanno, J.B, Calarese, D.A, Celikgil, A, Chamala, S, Chan, M.K, Chaparro, R, Evans, B, Garforth, S, Gizzi, A, Hillerich, B, Kar, A, Lafleur, J, Lim, S, Love, J, Matikainen, B, Patel, H, Seidel, R.D, Smith, B, Stead, M, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2012-04-23 | | Release date: | 2012-05-09 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Solution structure of human C-type lectin domain family 4 member D
To be Published
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2HGM
 | | NMR structure of the second qRRM domain of human hnRNP F | | Descriptor: | Heterogeneous nuclear ribonucleoprotein F | | Authors: | Dominguez, C, Allain, F.H.-T. | | Deposit date: | 2006-06-27 | | Release date: | 2006-07-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
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2LCE
 | | Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast Structural Genomics Consortium | | Descriptor: | B-cell lymphoma 6 protein, ZINC ION | | Authors: | Lee, H, Shastry, R, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-04-28 | | Release date: | 2011-05-18 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of Hr4436B.
To be Published
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2HPZ
 | | Crystal structure of proteinase K complex with a synthetic peptide KLKLLVVIRLK at 1.69 A resolution | | Descriptor: | 11-mer synthetic peptide, CALCIUM ION, NITRATE ION, ... | | Authors: | Prem kumar, R, Singh, A.K, Somvanshi, R.K, Singh, N, Sharma, S, Kaur, P, Dey, S, Bhushan, A, Singh, T.P. | | Deposit date: | 2006-07-18 | | Release date: | 2006-08-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal structure of proteinase K complex with a synthetic peptide KLKLLVVIRLK at 1.69 A resolution
To be Published
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6YUL
 | | CK2 alpha bound to Macrocycle | | Descriptor: | 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION | | Authors: | Kraemer, A, Hanke, T, Kurz, C, Celik, I, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-04-27 | | Release date: | 2020-07-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.
Eur.J.Med.Chem., 208, 2020
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2LIR
 | | NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in oxidized states | | Descriptor: | Cytochrome c iso-1, HEME C | | Authors: | Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X. | | Deposit date: | 2011-08-31 | | Release date: | 2011-12-07 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
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4IX5
 | | Crystal structure of a Stt7 homolog from Micromonas algae in complex with AMP-PNP | | Descriptor: | MAGNESIUM ION, MsStt7d protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Guo, J, Wei, X, Li, M, Pan, X, Chang, W, Liu, Z. | | Deposit date: | 2013-01-24 | | Release date: | 2013-10-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae
Protein Cell, 4, 2013
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2LSN
 | | Solution structure of PFV RNase H domain | | Descriptor: | RNase H | | Authors: | Leo, B, Schweimer, K, Woehrl, B. | | Deposit date: | 2012-05-03 | | Release date: | 2012-10-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding.
Retrovirology, 9, 2012
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6YZ4
 | | Crystal structure of MKK7 (MAP2K7) with ibrutinib bound at allosteric site | | Descriptor: | 1,2-ETHANEDIOL, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, DIMETHYL SULFOXIDE, ... | | Authors: | Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-05-06 | | Release date: | 2020-08-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.
Cell Chem Biol, 27, 2020
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2HOG
 | | crystal structure of Chek1 in complex with inhibitor 20 | | Descriptor: | (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL, Serine/threonine-protein kinase Chk1 | | Authors: | Yan, Y, Ikuta, M. | | Deposit date: | 2006-07-14 | | Release date: | 2007-04-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.
Bioorg.Med.Chem.Lett., 16, 2006
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2HI3
 | | Solution structure of the homeodomain-only protein HOP | | Descriptor: | Homeodomain-only protein | | Authors: | Mackay, J.P, Kook, H, Epstein, J.A, Simpson, R.J, Yung, W.W. | | Deposit date: | 2006-06-28 | | Release date: | 2007-01-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Analysis of the structure and function of the transcriptional coregulator HOP
Biochemistry, 45, 2006
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2LRC
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2HIU
 | | NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES | | Descriptor: | INSULIN | | Authors: | Hua, Q.X, Gozani, S.N, Chance, R.E, Hoffmann, J.A, Frank, B.H, Weiss, M.A. | | Deposit date: | 1996-10-08 | | Release date: | 1997-04-01 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
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2LPR
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2MBW
 | | RECOMBINANT SPERM WHALE MYOGLOBIN (MET) | | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Brucker, E.A, Phillips Jr, G.N. | | Deposit date: | 1996-06-20 | | Release date: | 1996-12-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin.
J.Biol.Chem., 271, 1996
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2MGM
 | | HIGH RESOLUTION CRYSTAL STRUCTURES OF FIVE DISTAL HISTIDINE MUTANTS OF SPERM WHALE MYOGLOBIN | | Descriptor: | MYOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Quillin, M.L, Arduini, R.M, Phillips Jr, G.N. | | Deposit date: | 1993-05-10 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin.
J.Mol.Biol., 234, 1993
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2MGA
 | | HIGH RESOLUTION CRYSTAL STRUCTURES OF FIVE DISTAL HISTIDINE MUTANTS OF SPERM WHALE MYOGLOBIN | | Descriptor: | CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Quillin, M.L, Arduini, R.M, Phillips Jr, G.N. | | Deposit date: | 1993-05-10 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin.
J.Mol.Biol., 234, 1993
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2HKY
 | | NMR solution structure of human RNase 7 | | Descriptor: | Ribonuclease 7 | | Authors: | Huang, Y.-C, Chen, C, Lou, Y.-C. | | Deposit date: | 2006-07-06 | | Release date: | 2006-12-26 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.
J.Biol.Chem., 282, 2007
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6Z36
 | | Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118 | | Descriptor: | 1,2-ETHANEDIOL, 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine, AMMONIUM ION, ... | | Authors: | Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | | Deposit date: | 2020-05-19 | | Release date: | 2020-05-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118
To Be Published
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2MGC
 | | HIGH RESOLUTION CRYSTAL STRUCTURES OF FIVE DISTAL HISTIDINE MUTANTS OF SPERM WHALE MYOGLOBIN | | Descriptor: | CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Arduini, R.M, Quillin, M.L, Phillips Jr, G.N. | | Deposit date: | 1993-05-10 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin.
J.Mol.Biol., 234, 1993
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2MGG
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