4NDK
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4NDJ
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6C9I
| Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins - Scaffold | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | Deposit date: | 2018-01-26 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6C9K
| Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | Deposit date: | 2018-01-26 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3R2X
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3LJM
| Structure of de novo designed apo peptide coil SER L9C | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COIL SER L9C, ... | Authors: | Chakraborty, S. | Deposit date: | 2010-01-26 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Structural comparisons of apo- and metalated three-stranded coiled coils clarify metal binding determinants in thiolate containing designed peptides. J.Am.Chem.Soc., 132, 2010
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4PN8
| A de novo designed pentameric coiled coil CC-Pent. | Descriptor: | CC-Pent | Authors: | Wood, C.W, Burton, A.J, Thomson, A.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2014-05-23 | Release date: | 2014-10-22 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Computational design of water-soluble alpha-helical barrels. Science, 346, 2014
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2KIK
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4J9T
| Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61 | Descriptor: | ARSENIC, GLYCEROL, designed unnatural amino acid dependent metalloprotein | Authors: | Forouhar, F, Lew, S, Seetharaman, J, Mills, J.H, Khare, S.D, Everett, J.K, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-02-17 | Release date: | 2013-03-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc., 135, 2013
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2MLB
| NMR solution structure of a computational designed protein based on template of human erythrocytic ubiquitin | Descriptor: | redesigned ubiquitin | Authors: | Xiong, P, Wang, M, Zhang, J, Chen, Q, Liu, H. | Deposit date: | 2014-02-21 | Release date: | 2014-10-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability Nat Commun, 5, 2014
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6JCC
| structure of a de novo protein D_1CY5_M1 | Descriptor: | Computational designed protein based on evolution | Authors: | Meng, W, Feng, T. | Deposit date: | 2019-01-28 | Release date: | 2019-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | structure of a computationally designed mutant protein D_1CY5_M1 To Be Published
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8VSW
| 4-MERCAPTOPHENOL-ALPHA3C | Descriptor: | 4-mercaptophenol-alpha3C protein, 4-sulfanylphenol | Authors: | Tommos, C. | Deposit date: | 2024-01-24 | Release date: | 2024-03-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Switching the proton-coupled electron transfer mechanism for non-canonical tyrosine residues in a de novo protein. Chem Sci, 15, 2024
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7DCL
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6LDF
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6LDE
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6LDG
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6FDB
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3V45
| Crystal Structure of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium Target OR130 | Descriptor: | CHLORIDE ION, SODIUM ION, Serine hydrolase OSH55 | Authors: | Kuzin, A, Su, M, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-12-14 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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5WP3
| Crystal Structure of EED in complex with EB22 | Descriptor: | EB22, Polycomb protein EED, UNKNOWN ATOM OR ION | Authors: | Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2017-08-03 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ER6
| Crystal structure of a computationally designed colicin endonuclease and immunity pair colEdes7/Imdes7 | Descriptor: | Endonuclease colEdes7, immunity Imdes7 | Authors: | Netzer, R, Listov, D, Dym, O, Albeck, S, Knop, O, Fleishman, S.J. | Deposit date: | 2017-10-17 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Ultrahigh specificity in a network of computationally designed protein-interaction pairs. Nat Commun, 9, 2018
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4ESS
| Crystal Structure of E6D/L155R variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR187 | Descriptor: | OR187 | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-23 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9971 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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4ETJ
| Crystal Structure of E6H variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR185 | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CHLORIDE ION, ... | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-24 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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6VFL
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8ED3
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6OHH
| Structure of EF1p2_mFAP2b bound to DFHBI | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, CALCIUM ION, EF1p2_mFAP2b | Authors: | Doyle, L.A, Stoddard, B.L. | Deposit date: | 2019-04-05 | Release date: | 2020-04-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Incorporation of sensing modalities into de novo designed fluorescence-activating proteins Nat Commun, 12, 2021
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