PDB: 202 resultsInfo pagesStatus searchChemie searchBIRD

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6U41	1.7 angstrom structure of a pathogenic human Syt 1 C2B (D304G) Descriptor: SULFATE ION, Synaptotagmin-1 Authors: Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. Deposit date: 2019-08-22 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
6U4U	1.3 A structure of a pathogenic human Syt 1 C2B (I368T) Descriptor: SULFATE ION, Synaptotagmin-1 Authors: Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. Deposit date: 2019-08-26 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
7ATP	2.0 angstrom structure in complex with Ca of plant Extended Synaptotagmin 1, C2A domain Descriptor: CALCIUM ION, CHLORIDE ION, Synaptotagmin-1, ... Authors: Benavente, J.L, Albert, A. Deposit date: 2020-10-30 Release date: 2021-08-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites. Life Sci Alliance, 4, 2021
7AS6	2.0 angstrom structure of plant Extended Synaptotagmin 1, C2A domain Descriptor: 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... Authors: Benavente, J.L, Albert, A. Deposit date: 2020-10-27 Release date: 2021-08-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites. Life Sci Alliance, 4, 2021
4ICX	N-terminal C2 domain of human CEP120 Descriptor: Centrosomal protein of 120 kDa Authors: Janowski, R, Guarin, N, Coll, M. Deposit date: 2012-12-11 Release date: 2014-06-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: N-terminal C2 domain tandem of human CEP120 shows lipid binding properties To be Published
4IHB	X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN Descriptor: CALCIUM ION, Dysferlin, FORMIC ACID Authors: Sutton, R.B, Fuson, K.L. Deposit date: 2012-12-18 Release date: 2013-12-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.044 Å) Cite: Alternate Splicing of Dysferlin C2A Confers Ca(2+)-Dependent and Ca(2+)-Independent Binding for Membrane Repair. Structure, 22, 2014
7A1R	Crystal structure of the C2B domain of Trypanosoma brucei extended synaptotagmin (E-Syt) Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ... Authors: Dong, G. Deposit date: 2020-08-13 Release date: 2021-06-02 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei . Iscience, 24, 2021
6U4W	1.4 A structure of a pathogenic human Syt 1 C2B (D366E) Descriptor: SULFATE ION, Synaptotagmin-1 Authors: Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. Deposit date: 2019-08-26 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
6KXT	BON1-C2B Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Protein BONZAI 1, SULFATE ION Authors: Wang, Q.C, Jiang, M.Q, Isupov, M.N, Sun, L.F, Wu, Y.K. Deposit date: 2019-09-12 Release date: 2020-09-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal Structure of an Arabidopsis Copine providing insights into this protein family To be published
5CCJ	Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain Descriptor: GLYCEROL, SULFATE ION, Synaptotagmin-1 Authors: Zhou, Q, Zhao, M, Brunger, A.T. Deposit date: 2015-07-02 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
2NSQ	Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL Authors: Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2006-11-06 Release date: 2006-12-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein To be Published
3N5A	Synaptotagmin-7, C2B-domain, calcium bound Descriptor: CALCIUM ION, Synaptotagmin-7 Authors: Tomchick, D.R, Rizo, J, Craig, T.K. Deposit date: 2010-05-24 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.441 Å) Cite: Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. Plos One, 5, 2010
5A51	The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and phophatidyl serine Descriptor: AT3G17980, CALCIUM ION, PHOSPHOSERINE Authors: Diaz, M, Albert, A. Deposit date: 2015-06-16 Release date: 2016-03-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling. Proc.Natl.Acad.Sci.USA, 113, 2016
4RJ9	Structure of a plant specific C2 domain protein, OsGAP1 from rice Descriptor: C2 domain-containing protein-like, POTASSIUM ION Authors: Miao, R, Fong, Y.H, Wong, K.B, Lam, H.M. Deposit date: 2014-10-08 Release date: 2015-08-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1). J.Biol.Chem., 290, 2015
4TS6	Crystal structure of the RIM C2A domain from Drosophila. Descriptor: GLYCEROL, Rab3 interacting molecule variant 2 Authors: Hatzopoulos, G.N, Shiroma, J, Vakonakis, I. Deposit date: 2014-06-18 Release date: 2015-07-01 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystal structure of the RIM C2A domain from Drosophila. To Be Published
3PYC	Crystal structure of human SMURF1 C2 domain Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase SMURF1, SULFATE ION Authors: Li, X, Li, P. Deposit date: 2010-12-13 Release date: 2011-04-06 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Crystal structure of human SMURF1 C2 domain To be Published
2Q3X	The RIM1alpha C2B domain Descriptor: CHLORIDE ION, Regulating synaptic membrane exocytosis protein 1, SODIUM ION, ... Authors: Guan, R, Dai, H, Tomchick, D.R, Machius, M, Sudhof, T.C, Rizo, J. Deposit date: 2007-05-30 Release date: 2007-08-28 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the RIM1alpha C(2)B Domain at 1.7 A Resolution. Biochemistry, 46, 2007
2NCE	Solution Structure of Ca2+-bound C2 domain from Protein Kinase C alpha in the form of complex with V5-pHM peptide Descriptor: CALCIUM ION, Protein kinase C alpha type Authors: Yang, Y, Igumenova, T.I. Deposit date: 2016-03-28 Release date: 2017-03-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Ca2+-sensing domain contributes to auto-inhibition of protein kinase Calpha through interactions with C-terminal tail To be Published
2NQ3	Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase Descriptor: CHLORIDE ION, Itchy homolog E3 ubiquitin protein ligase Authors: Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2006-10-30 Release date: 2006-11-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase To be Published
6ANK	Synaptotagmin-7, C2A- and C2B-domains Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7 Authors: Tomchick, D.R, Rizo, J, Voleti, R. Deposit date: 2017-08-13 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.254 Å) Cite: Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BTZ	Crystal structure of the PI3KC2alpha C2 domain in space group C121 Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, GLYCEROL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ... Authors: Chen, K.-E, Collins, B.M. Deposit date: 2017-12-08 Release date: 2018-10-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
6CXW	Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function Descriptor: Synaptotagmin 1 C2A beta4 chimera Authors: Sutton, R.B. Deposit date: 2018-04-04 Release date: 2019-04-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.832 Å) Cite: Engineering a C2-domain to bind PIP2 To Be Published
6BTY	Crystal structure of the PI3KC2alpha C2 domain in space group P41212 Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Authors: Chen, K.-E, Collins, B.M. Deposit date: 2017-12-08 Release date: 2018-10-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.678 Å) Cite: Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
6BU0	Crystal structure of the PI3KC2alpha C2 domain in complex with IP6 Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, FORMIC ACID, INOSITOL HEXAKISPHOSPHATE, ... Authors: Chen, K.-E, Collins, B.M. Deposit date: 2017-12-08 Release date: 2018-10-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.427 Å) Cite: Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
6ANJ	Synaptotagmin-7, C2A domain Descriptor: ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... Authors: Tomchick, D.R, Rizo, J, Voleti, R. Deposit date: 2017-08-13 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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