6BU0

Crystal structure of the PI3KC2alpha C2 domain in complex with IP6

Summary for 6BU0

Entry DOI	10.2210/pdb6bu0/pdb
Related	2B3R 6BTY 6BTZ
Descriptor	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, FORMIC ACID, INOSITOL HEXAKISPHOSPHATE, ... (5 entities in total)
Functional Keywords	c2 domain, lipid binding, phosphoinositide, pi3-kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	47750.93
Authors	Chen, K.-E.,Collins, B.M. (deposition date: 2017-12-08, release date: 2018-10-17, Last modification date: 2023-10-04)
Primary citation	Chen, K.E.,Tillu, V.A.,Chandra, M.,Collins, B.M. Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26:1612-, 2018 Cited by PubMed: 30293811 DOI: 10.1016/j.str.2018.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.427 Å)

Structure validation