PDB: 26892 resultsInfo pagesStatus searchChemie searchBIRD

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5XN3	Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction Descriptor: SPRY domain-containing SOCS box protein 2, cR8 peptide from NOS2 Authors: You, T, Kuang, Z. Deposit date: 2017-05-17 Release date: 2017-06-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction. Biochem. Biophys. Res. Commun., 489, 2017
6U5M	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-2-hydroxy-N-[3-(methylsulfonyl)-5-(pentafluoro-lambda~6~-sulfanyl)phenyl]benzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-08-28 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6U8B	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-5-chloro-2-hydroxybenzoic acid, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-04 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.261 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
3EMH	Structural basis of WDR5-MLL interaction Descriptor: Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5 Authors: Song, J.J, Kingston, R.E. Deposit date: 2008-09-24 Release date: 2008-10-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.37 Å) Cite: WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. J.Biol.Chem., 283, 2008
6U6W	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-08-30 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6O8X	Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class02 Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Jogl, G, Khayat, R. Deposit date: 2019-03-12 Release date: 2020-09-23 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Sci Rep, 10, 2020
6OI3	Crystal structure of human WDR5 in complex with monomethyl H3R2 peptide Descriptor: GLYCEROL, Monomethyl H3R2 peptide, SULFATE ION, ... Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-08 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.66 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OIK	Muscarinic acetylcholine receptor 2-Go complex Descriptor: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ... Authors: Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. Deposit date: 2019-04-09 Release date: 2019-05-08 Last modified: 2020-01-08 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. Deposit date: 2019-09-26 Release date: 2020-12-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
8F76	Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Billesboelle, C.B, Manglik, A. Deposit date: 2022-11-18 Release date: 2023-03-22 Last modified: 2023-04-05 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of odorant recognition by a human odorant receptor. Nature, 615, 2023
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747 Descriptor: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Bouley, R, Tesmer, J.J.G. Deposit date: 2019-09-02 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.44 Å) Cite: A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
6U8L	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid, N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
5XMM	FLA-E*01801-167W/S Descriptor: Beta-2-microglobulin, Gag polyprotein, MHC class I antigen alpha chain Authors: Liang, R, Sun, Y, Wang, J, Wu, Y, Zhang, N, Xia, C. Deposit date: 2017-05-15 Release date: 2017-12-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides J. Virol., 92, 2018
6OM7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-18 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6OI1	Crystal structure of human WDR5 in complex with monomethyl L-arginine Descriptor: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, GLYCEROL, SULFATE ION, ... Authors: Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. Deposit date: 2019-04-08 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.68 Å) Cite: A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6UJ4	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-10-02 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJL	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5 Authors: Phan, J. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6OLZ	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-17 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6UJJ	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: 5-[4-(trifluoromethyl)phenyl]-1H-tetrazole, WD repeat-containing protein 5 Authors: Phan, J. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.731 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
8EMW	Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Falzone, M.E, MacKinnon, R. Deposit date: 2022-09-28 Release date: 2023-05-24 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface. Proc.Natl.Acad.Sci.USA, 120, 2023
8EMX	Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Falzone, M.E, MacKinnon, R. Deposit date: 2022-09-28 Release date: 2023-05-24 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface. Proc.Natl.Acad.Sci.USA, 120, 2023
3EI4	Structure of the hsDDB1-hsDDB2 complex Descriptor: DNA damage-binding protein 1, DNA damage-binding protein 2 Authors: Scrima, A, Pavletich, N.P, Thoma, N.H. Deposit date: 2008-09-15 Release date: 2009-01-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell(Cambridge,Mass.), 135, 2008
3EG6	Structure of WDR5 bound to MLL1 peptide Descriptor: MLL-1 peptide, SULFATE ION, WD repeat-containing protein 5 Authors: Patel, A, Dharmarajan, V, Cosgrove, M.S. Deposit date: 2008-09-10 Release date: 2008-09-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J.Biol.Chem., 283, 2008
6O8W	Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class01 Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Jogl, G, Khayat, R. Deposit date: 2019-03-12 Release date: 2020-09-23 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Sci Rep, 10, 2020

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