3C91
| Thermoplasma acidophilum 20S proteasome with an open gate | Descriptor: | Proteasome subunit alpha, Proteasome subunit beta | Authors: | Rabl, J, Smith, D.M, Yu, Y, Chang, S.C, Goldberg, A.L, Cheng, Y. | Deposit date: | 2008-02-14 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol.Cell, 30, 2008
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5G3L
| ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER COMPLEXED WITH SIALYLATED SUGAR | Descriptor: | HEAT-LABILE ENTEROTOXIN IIB, B CHAIN, N-acetyl-alpha-neuraminic acid, ... | Authors: | Zalem, D, Benktander, J, Ribeiro, J.P, Varrot, A, Lebens, M, Imberty, A, Teneberg, S. | Deposit date: | 2016-04-29 | Release date: | 2016-09-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Biochemical and Structural Characterization of the Novel Sialic Acid-Binding Site of Escherichia Coli Heat-Labile Enterotoxin Lt-Iib. Biochem.J., 473, 2016
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5L7D
| Structure of human Smoothened in complex with cholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SODIUM ION, ... | Authors: | Byrne, E.F.X, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.P, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C. | Deposit date: | 2016-06-03 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of Smoothened regulation by its extracellular domains. Nature, 535, 2016
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2PRL
| The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site | Descriptor: | 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | Authors: | Walse, B, Dufe, V.T, Al-Karadaghi, S. | Deposit date: | 2007-05-04 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47, 2008
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5KVI
| Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Apoptosis-inducing factor 1, mitochondrial, ... | Authors: | Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A. | Deposit date: | 2016-07-14 | Release date: | 2016-11-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure, 24, 2016
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4ZB7
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5KYW
| crystal structure of Sec23 and TANGO1 peptide3 complex | Descriptor: | Protein transport protein Sec23A, Protein transport protein Sec24D, TANGO1 peptide3, ... | Authors: | Ma, W, Goldberg, J. | Deposit date: | 2016-07-22 | Release date: | 2016-09-07 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. Proc.Natl.Acad.Sci.USA, 113, 2016
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1HVY
| Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, THYMIDYLATE SYNTHASE, ... | Authors: | Phan, J, Koli, S, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | Deposit date: | 2001-01-08 | Release date: | 2001-01-31 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug Biochemistry, 40, 2001
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1HSK
| CRYSTAL STRUCTURE OF S. AUREUS MURB | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE | Authors: | Benson, T.E, Harris, M.S, Choi, G.H, Cialdella, J.I, Herberg, J.T, Martin Jr, J.P, Baldwin, E.T. | Deposit date: | 2000-12-27 | Release date: | 2001-03-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Biochemistry, 40, 2001
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5DRZ
| Crystal structure of anti-HIV-1 antibody F240 Fab in complex with gp41 peptide | Descriptor: | Envelope glycoprotein gp160, HIV Antibody F240 Heavy Chain, HIV Antibody F240 Light Chain, ... | Authors: | Gohain, N, Tolbert, W.D, Pazgier, M. | Deposit date: | 2015-09-16 | Release date: | 2016-10-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240. Sci Rep, 6, 2016
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1HXY
| CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II | Descriptor: | ENTEROTOXIN H, HEMAGGLUTININ, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ... | Authors: | Petersson, K, Hakansson, M, Nilsson, H, Forsberg, G, Svensson, L.A, Liljas, A, Walse, B. | Deposit date: | 2001-01-17 | Release date: | 2001-06-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of a Superantigen Bound to MHC Class II Displays Zinc and Peptide Dependence Embo J., 20, 2001
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1HLG
| CRYSTAL STRUCTURE OF HUMAN GASTRIC LIPASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LIPASE, ... | Authors: | Roussel, A, Canaan, S, Verger, R, Cambillau, C. | Deposit date: | 1999-03-12 | Release date: | 2000-03-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. J.Biol.Chem., 274, 1999
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2BAY
| Crystal structure of the Prp19 U-box dimer | Descriptor: | Pre-mRNA splicing factor PRP19 | Authors: | Vander Kooi, C.W, Ohi, M.D, Rosenberg, J.A, Oldham, M.L, Newcomer, M.E, Gould, K.L, Chazin, W.J. | Deposit date: | 2005-10-15 | Release date: | 2006-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Prp19 U-box Crystal Structure Suggests a Common Dimeric Architecture for a Class of Oligomeric E3 Ubiquitin Ligases. Biochemistry, 45, 2006
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1HLF
| BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD | Descriptor: | (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Oikonomakos, N.G, Skamnaki, V.T, Docsa, T, Toth, B, Gergely, P, Osz, E, Szilagyi, L, Somsak, L. | Deposit date: | 2000-12-01 | Release date: | 2000-12-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin
binding to glycogen phosphorylase B BIOORG.MED.CHEM., 10, 2002
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2B61
| Crystal Structure of Homoserine Transacetylase | Descriptor: | Homoserine O-acetyltransferase | Authors: | Mirza, I.A, Nazi, I, Korczynska, M, Wright, G.D, Berghuis, A.M. | Deposit date: | 2005-09-29 | Release date: | 2005-11-15 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of Homoserine Transacetylase from Haemophilus influenzae Reveals a New Family of alpha/beta-Hydrolases Biochemistry, 44, 2005
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1HW7
| HSP33, HEAT SHOCK PROTEIN WITH REDOX-REGULATED CHAPERONE ACTIVITY | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HEAT SHOCK PROTEIN HSP33, SULFATE ION, ... | Authors: | Vijayalakshmi, J, Mukhergee, M.K, Graumann, J, Jakob, U, Saper, M.A. | Deposit date: | 2001-01-09 | Release date: | 2001-05-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity. Structure, 9, 2001
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4Z0X
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5E5V
| Structure of amyloid forming peptide NFGAILS (residues 22-28) from Islet Amyloid Polypeptide | Descriptor: | NFGAILS (22-28) from islet amyloid polypeptide, synthesized | Authors: | Soriaga, A.B, Macdonald, R, Sawaya, M.R, Sangwan, S, Eisenberg, D. | Deposit date: | 2015-10-09 | Release date: | 2015-12-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J.Phys.Chem.B, 120, 2016
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5E5Z
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2B8P
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2KUA
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1HU3
| MIDDLE DOMAIN OF HUMAN EIF4GII | Descriptor: | EIF4GII | Authors: | Marcotrigiano, J, Lomakin, I, Pestova, T.V, Hellen, C.U.T, Sonenberg, N, Burley, S.K. | Deposit date: | 2001-01-03 | Release date: | 2001-02-21 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol.Cell, 7, 2001
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2ZII
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4ZB6
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1KTI
| BINDING OF 100 MM N-ACETYL-N'-BETA-D-GLUCOPYRANOSYL UREA TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUDIES | Descriptor: | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-(acetylcarbamoyl)-beta-D-glucopyranosylamine, ... | Authors: | Oikonomakos, N.G, Kosmopoulou, M, Zographos, S.E, Leonidas, D.D, Chrysina, E.D, Somsak, L, Nagy, V, Praly, J.P, Docsa, T, Toth, B, Gergely, P. | Deposit date: | 2002-01-16 | Release date: | 2002-01-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Binding of N-acetyl-N'-beta-D-glucopyranosyl urea and N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur.J.Biochem., 269, 2002
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