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3W1G	Crystal Structure of Human DNA ligase IV-Artemis Complex (Native) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Artemis-derived peptide, DNA ligase 4, ... Authors: Ochi, T, Blundell, T.L. Deposit date: 2012-11-15 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair Structure, 21, 2013
5TT6	T4 RNA Ligase 1 (K99M) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, T4 RNA ligase 1 Authors: Goldgur, Y, Unciuleac, M.-C, Shuman, S.H. Deposit date: 2016-11-01 Release date: 2017-03-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.187 Å) Cite: Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7ELT	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Trp-AMP Descriptor: TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase Authors: Xu, M, Chen, S. Deposit date: 2021-04-12 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7EL8	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase Descriptor: Tryptophan--tRNA ligase Authors: Xu, M, Chen, S. Deposit date: 2021-04-09 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
5C7M	CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT Descriptor: E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C Authors: Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) Deposit date: 2015-06-24 Release date: 2016-03-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.03 Å) Cite: System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
7ENS	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Indolmycin and ATP Descriptor: (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Xu, M, Chen, S. Deposit date: 2021-04-19 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7ENT	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-13 and ATP Descriptor: (5S)-2-(methylamino)-5-[(1R)-1-(4-methyl-1H-indol-3-yl)ethyl]-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Xu, M, Chen, S. Deposit date: 2021-04-19 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 Descriptor: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 Authors: Diao, J, Lin, D.Y, Chen, J. Deposit date: 2011-07-15 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
2RNN	Solution Structure of the N-terminal SAP Domain of SUMO E3 Ligases from Saccharomyces cerevisiae Descriptor: E3 SUMO-protein ligase SIZ1 Authors: Suzuki, R, Shindo, H, Tase, A, Yamazaki, T. Deposit date: 2008-01-30 Release date: 2008-12-30 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structures and DNA binding properties of the N-terminal SAP domains of SUMO E3 ligases from Saccharomyces cerevisiae and Oryza sativa. Proteins, 75, 2009
5TT5	Escherichia coli LigA (K115M) in complex with NAD+ Descriptor: DNA ligase, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Goldgur, Y, Unciuleac, M.-C, Shuman, S.H. Deposit date: 2016-11-01 Release date: 2017-03-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.552 Å) Cite: Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3W1B	Crystal Structure of Human DNA ligase IV-Artemis Complex (Mercury Derivative) Descriptor: ADENOSINE MONOPHOSPHATE, Artemis-derived peptide, DNA ligase 4, ... Authors: Ochi, T, Blundell, T.L. Deposit date: 2012-11-14 Release date: 2013-04-03 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair Structure, 21, 2013
3W5O	Crystal Structure of Human DNA ligase IV Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA ligase 4, SULFATE ION Authors: Gu, X, Ochi, T, Blundell, T.L. Deposit date: 2013-02-02 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair Structure, 21, 2013
8IUG	Cryo-EM structure of the RC-LH core complex from roseiflexus castenholzii Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... Authors: Wang, G.-L, Qi, C.-H, Yu, L.-J. Deposit date: 2023-03-24 Release date: 2023-11-22 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: New insights on the photocomplex of Roseiflexus castenholzii revealed from comparisons of native and carotenoid-depleted complexes. J.Biol.Chem., 299, 2023
6U1C	Apo form of Thermus thermophilus D-alanine-D-alanine ligase Descriptor: D-alanine--D-alanine ligase Authors: Pederick, J.L, Bruning, J.B. Deposit date: 2019-08-15 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
8IUN	Cryo-EM structure of the CRT-LESS RC-LH core complex from roseiflexus castenholzii Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... Authors: Wang, G.-L, Qi, C.-H, Yu, L.-J. Deposit date: 2023-03-24 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: New insights on the photocomplex of Roseiflexus castenholzii revealed from comparisons of native and carotenoid-depleted complexes. J.Biol.Chem., 299, 2023
6U1D	Thermus thermophilus D-alanine-D-alanine ligase in complex with ATP, D-alanine-D-alanine, Mg2+ and Rb+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, D-ALANINE, D-alanine--D-alanine ligase, ... Authors: Pederick, J.L, Bruning, J.B. Deposit date: 2019-08-15 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
6U1E	Thermus thermophilus D-alanine-D-alanine ligase in complex with ATP, D-alanine-D-alanine, Mg2+ and Rb+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, D-ALANINE, D-alanine--D-alanine ligase, ... Authors: Pederick, J.L, Bruning, J.B. Deposit date: 2019-08-15 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
6JOM	Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae Descriptor: 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, Lipoate--protein ligase Authors: Zhang, H, Chen, H, Ma, G. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae. Front Cell Infect Microbiol, 10, 2020
3IG8	Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+, L-glutamate and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Glutamate-cysteine ligase, ... Authors: Biterova, E, Barycki, J.J. Deposit date: 2009-07-27 Release date: 2009-09-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase. J.Biol.Chem., 284, 2009
4DQ2	Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp Descriptor: ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Biotin-[acetyl-CoA-carboxylase] ligase Authors: Wilce, M, Yap, M, Pendini, N, Soares de Costa, T, Polyak, S, Tieu, W, Booker, G, Wallace, J. Deposit date: 2012-02-14 Release date: 2012-04-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
3IG5	Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+ and L-glutamate Descriptor: GLUTAMIC ACID, Glutamate-cysteine ligase, MAGNESIUM ION, ... Authors: Biterova, E, Barycki, J.J. Deposit date: 2009-07-27 Release date: 2009-09-01 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase. J.Biol.Chem., 284, 2009
4WHV	E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B Descriptor: E3 ubiquitin-protein ligase RNF8, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 N, ... Authors: Hodge, C.D, Edwards, R.A, Glover, J.N.M. Deposit date: 2014-09-23 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (8.3 Å) Cite: RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment. J.Biol.Chem., 291, 2016
4ME6	Crystal structure of D-alanine-D-alanine ligase A from Xanthomonas oryzae pathovar oryzae with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-alanine--D-alanine ligase, MAGNESIUM ION Authors: Doan, T.T.N, Kim, J.K, Ahn, Y.J, Lee, B.M, Kang, L.W. Deposit date: 2013-08-25 Release date: 2014-02-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides Arch.Biochem.Biophys., 545C, 2014
7MO6	Guanosine Monophosphate Synthase from Aspergillus fumigatus Af293 Descriptor: GMP synthase [glutamine-hydrolyzing] Authors: Nguyen, S, Bruning, J.B. Deposit date: 2021-05-01 Release date: 2022-02-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus. Acta Crystallogr D Struct Biol, 78, 2022
3PC7	X-ray crystal structure of the DNA ligase III-alpha BRCT domain. Descriptor: DNA ligase 3 Authors: Cuneo, M.J, Krahn, J.M, London, R.E. Deposit date: 2010-10-21 Release date: 2011-06-15 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The structural basis for partitioning of the XRCC1/DNA ligase III-{alpha} BRCT-mediated dimer complexes. Nucleic Acids Res., 39, 2011

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