7W1Y
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![BU of 7w1y by Molmil](/molmil-images/mine/7w1y) | Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | Authors: | Li, J, Dong, J, Dang, S, Zhai, Y. | Deposit date: | 2021-11-21 | Release date: | 2023-02-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | The human pre-replication complex is an open complex. Cell, 186, 2023
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7X6R
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![BU of 7x6r by Molmil](/molmil-images/mine/7x6r) | Crystal structure of actinomycin D-echinomycin-d(AGCACGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, COBALT (II) ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-08 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7X97
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![BU of 7x97 by Molmil](/molmil-images/mine/7x97) | Crystal structure of actinomycin D-echinomycin-d(AGCCCGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, CHLORIDE ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-15 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7XDJ
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![BU of 7xdj by Molmil](/molmil-images/mine/7xdj) | Crystal structure of actinomycin D-echinomycin-d(AGCGCGT/ACGAGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, CHLORIDE ION, DNA (5'-D(P*AP*CP*GP*AP*GP*CP*(BRU))-3'), ... | Authors: | Chien, C.M, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-27 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.435 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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6I11
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![BU of 6i11 by Molmil](/molmil-images/mine/6i11) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3 | Descriptor: | ACETATE ION, Fascin, ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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6I10
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![BU of 6i10 by Molmil](/molmil-images/mine/6i10) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 2 | Descriptor: | 1,2-ETHANEDIOL, 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one, ACETATE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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7UJU
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![BU of 7uju by Molmil](/molmil-images/mine/7uju) | Room-temperature X-ray structure of monomeric SARS-CoV-2 main protease catalytic domain (MPro1-196) in complex with nirmatrelvir | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Kovalevsky, A, Kneller, D.W, Coates, L. | Deposit date: | 2022-03-31 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain. Commun Biol, 5, 2022
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3JZ7
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![BU of 3jz7 by Molmil](/molmil-images/mine/3jz7) | |
7UJ9
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![BU of 7uj9 by Molmil](/molmil-images/mine/7uj9) | |
7UJG
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![BU of 7ujg by Molmil](/molmil-images/mine/7ujg) | |
6I17
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![BU of 6i17 by Molmil](/molmil-images/mine/6i17) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24 | Descriptor: | 1,2-ETHANEDIOL, 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-6-piperidin-4-yl-2,7-naphthyridine-4-carboxamide, ACETATE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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6I18
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![BU of 6i18 by Molmil](/molmil-images/mine/6i18) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176 | Descriptor: | 1,2-ETHANEDIOL, 5-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-1-piperidin-4-yl-~{N}-pyridin-4-yl-pyrazolo[4,3-c]pyridine-7-carboxamide, ACETATE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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4N43
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7V94
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![BU of 7v94 by Molmil](/molmil-images/mine/7v94) | Cryo-EM structure of the Cas12c2-sgRNA-target DNA ternary complex | Descriptor: | Cas12c2, sgRNA, target DNA (non target strand), ... | Authors: | Kurihara, N, Hirano, H, Tomita, A, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-24 | Release date: | 2022-04-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure of the type V-C CRISPR-Cas effector enzyme. Mol.Cell, 82, 2022
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7V93
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![BU of 7v93 by Molmil](/molmil-images/mine/7v93) | Cryo-EM structure of the Cas12c2-sgRNA binary complex | Descriptor: | cas12c2, sgRNA | Authors: | Kurihara, N, Hirano, H, Tomita, A, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-24 | Release date: | 2022-04-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the type V-C CRISPR-Cas effector enzyme. Mol.Cell, 82, 2022
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6I0Z
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![BU of 6i0z by Molmil](/molmil-images/mine/6i0z) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1 | Descriptor: | Fascin, ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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6I13
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![BU of 6i13 by Molmil](/molmil-images/mine/6i13) | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7 | Descriptor: | 1,2-ETHANEDIOL, 2-[(3-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide, ACETATE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2018-10-27 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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1NKN
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![BU of 1nkn by Molmil](/molmil-images/mine/1nkn) | VISUALIZING AN UNSTABLE COILED COIL: THE CRYSTAL STRUCTURE OF AN N-TERMINAL SEGMENT OF THE SCALLOP MYOSIN ROD | Descriptor: | S2N51-GCN4 | Authors: | Li, Y, Brown, J.H, Reshetnikova, L, Blazsek, A, Farkas, L, Nyitray, L, Cohen, C. | Deposit date: | 2003-01-03 | Release date: | 2003-07-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Visualization of an unstable coiled coil from the scallop myosin rod Nature, 424, 2003
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4N53
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9BQ2
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![BU of 9bq2 by Molmil](/molmil-images/mine/9bq2) | |
8X7T
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![BU of 8x7t by Molmil](/molmil-images/mine/8x7t) | MCM in the Apo state. | Descriptor: | mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | MCM in the Apo state To Be Published
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8X7U
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![BU of 8x7u by Molmil](/molmil-images/mine/8x7u) | MCM in complex with dsDNA in presence of ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | MCM in complex with dsDNA in presence of ATP To Be Published
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6WVG
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![BU of 6wvg by Molmil](/molmil-images/mine/6wvg) | human CD53 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein, ... | Authors: | Yang, Y, Liu, S, Li, W. | Deposit date: | 2020-05-06 | Release date: | 2020-09-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Open conformation of tetraspanins shapes interaction partner networks on cell membranes. Embo J., 39, 2020
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6WXK
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![BU of 6wxk by Molmil](/molmil-images/mine/6wxk) | PHF23 PHD Domain Apo | Descriptor: | PHD finger protein 23, ZINC ION | Authors: | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | Deposit date: | 2020-05-11 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
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2IA6
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![BU of 2ia6 by Molmil](/molmil-images/mine/2ia6) | Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*A)-3', ... | Authors: | Bauer, J, Ling, H, Sayer, J.M, Xing, G, Yagi, H, Jerina, D.M. | Deposit date: | 2006-09-07 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc.Natl.Acad.Sci.Usa, 104, 2007
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