7X6R
Crystal structure of actinomycin D-echinomycin-d(AGCACGT/ACGGGCT) complex
Summary for 7X6R
| Entry DOI | 10.2210/pdb7x6r/pdb |
| Related PRD ID | PRD_000001 PRD_000491 |
| Descriptor | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*GP*GP*CP*T)-3'), Actinomycin D, ... (7 entities in total) |
| Functional Keywords | a:g mismatch, single-strand dna distortion, actinomycin d, echinomycin, mismatch binding drug, dna, dna-antibiotic complex, dna/antibiotic |
| Biological source | Streptomyces More |
| Total number of polymer chains | 4 |
| Total formula weight | 6854.41 |
| Authors | Kao, S.H.,Satange, R.B.,Hou, M.H. (deposition date: 2022-03-08, release date: 2022-12-14, Last modification date: 2023-11-29) |
| Primary citation | Satange, R.,Kao, S.H.,Chien, C.M.,Chou, S.H.,Lin, C.C.,Neidle, S.,Hou, M.H. Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50:8867-8881, 2022 Cited by PubMed: 35871296DOI: 10.1093/nar/gkac629 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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