2IA6

Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap

Summary for 2IA6

• Entry DOI: 10.2210/pdb2ia6/pdb
• Related: 2IBK
• Descriptor: DNA polymerase IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*A)-3', 5'-D(*TP*CP*AP*TP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... (10 entities in total)
• Functional Keywords: benzo pyrene, carcinogen, lesion bypass, polymerase, translesion synthesis, dpo4, transferase-dna complex, transferase/dna
• Biological source: Sulfolobus solfataricus
• Cellular location: Cytoplasm (Probable): Q97W02
• Total number of polymer chains: 6
• Total formula weight: 101411.65

Authors

Bauer, J.,Ling, H.,Sayer, J.M.,Xing, G.,Yagi, H.,Jerina, D.M. (deposition date: 2006-09-07, release date: 2007-09-11, Last modification date: 2023-08-30)

• Primary citation: Bauer, J.,Xing, G.,Yagi, H.,Sayer, J.M.,Jerina, D.M.,Ling, H.; A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.; Proc.Natl.Acad.Sci.Usa, 104:14905-14910, 2007; PubMed: 17848527; DOI: 10.1073/pnas.0700717104

Experimental method

X-RAY DIFFRACTION (2.5 Å)