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5LIG	G-Quadruplex formed at the 5'-end of NHEIII_1 Element in human c-MYC promoter bound to triangulenium based fluorescence probe DAOTA-M2 Descriptor: 8,12-bis(2-morpholinoethyl)-8H-benzo[ij]xantheno[1,9,8-cdef][2,7]naphthyridin-12-iumhexafluorophosphate, DNA (5'-D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3') Authors: Kotar, A, Wang, B, Shivalingam, A, Gonzalez-Garcia, J, Vilar, R, Plavec, J. Deposit date: 2016-07-14 Release date: 2016-09-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex. Angew.Chem.Int.Ed.Engl., 55, 2016
6JWE	structure of RET G-quadruplex in complex with colchicine Descriptor: DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide Authors: Wang, F, Wang, C, Liu, Y, Lan, W.X, Li, Y.M, Wang, R.X, Cao, C. Deposit date: 2019-04-20 Release date: 2020-02-26 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR. Chem.Commun.(Camb.), 56, 2020
6JWD	structure of RET G-quadruplex in complex with berberine Descriptor: BERBERINE, DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3') Authors: Wang, F, Wang, C, Liu, Y, Lan, W.X, Li, Y.M, Wang, R.X, Cao, C. Deposit date: 2019-04-19 Release date: 2020-04-22 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR. Chem.Commun.(Camb.), 56, 2020
6XT7	Tel25 Hybrid Four-quartet G-quadruplex with K+ Descriptor: DNA (25-MER), MAGNESIUM ION, POTASSIUM ION, ... Authors: Yatsunyk, L.A, McCarthy, S.E. Deposit date: 2020-07-17 Release date: 2020-12-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.56 Å) Cite: The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes. Nucleic Acids Res., 50, 2022
6K3X	G-quadruplex complex with linear dinucleotide d(AG) Descriptor: DNA (5'-D(*AP*G)-3'), DNA (5'-D(*TP*TP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') Authors: Winnerdy, F.R, Heddi, B, Phan, A.T. Deposit date: 2019-05-22 Release date: 2020-01-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides. J.Am.Chem.Soc., 141, 2019
7PNG	Solution structure of 1:1 complex of an indoloquinoline derivative SYUIQ-5 to parallel quadruplex-duplex (Q-D) hybrid Descriptor: DNA (37-MER), ~{N}-(5~{H}-indolo[3,2-b]quinolin-11-yl)-~{N}',~{N}'-dimethyl-propane-1,3-diamine Authors: Vianney, Y.M, Weisz, K. Deposit date: 2021-09-06 Release date: 2021-12-29 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Indoloquinoline Ligands Favor Intercalation at Quadruplex-Duplex Interfaces. Chemistry, 28, 2022
6LDM	Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA-binding protein RAP1, G-guadruplex DNA, ... Authors: Traczyk, A, Gill, D.J, Chong, W.L, Rhodes, D. Deposit date: 2019-11-22 Release date: 2020-03-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1. Nucleic Acids Res., 48, 2020
6ERL	Quadruplex with flipped tetrad formed by the c-myc promoter sequence Descriptor: cmbr-481317 Authors: Karg, B, Weisz, K. Deposit date: 2017-10-18 Release date: 2018-06-13 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Loop Length Affects Syn-Anti Conformational Rearrangements in Parallel G-Quadruplexes. Chemistry, 2018
7ATZ	G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite Descriptor: DNA (5'-D(*GP*GP*TP*CP*TP*GP*AP*GP*GP*GP*AP*GP*AP*GP*GP*GP*GP*CP*TP*GP*GP*GP*T)-3') Authors: Vianney, Y.M, Weisz, K. Deposit date: 2020-11-02 Release date: 2021-04-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure. Biochemistry, 60, 2021
6YY4	Parallel 17-mer DNA G-quadruplex Descriptor: DNA (5'-D(*GP*GP*GP*TP*GP*GP*GP*AP*AP*GP*GP*GP*TP*GP*GP*GP*A)-3') Authors: Srb, P, Curtis, C, Veverka, V. Deposit date: 2020-05-04 Release date: 2021-01-20 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Overlapping but distinct: a new model for G-quadruplex biochemical specificity. Nucleic Acids Res., 49, 2021
6ZRM	G-quadruplex with a G-A bulge Descriptor: DNA (5'-D(*TP*GP*GP*GP*AP*GP*GP*GP*AP*GP*CP*GP*GP*GP*AP*GP*TP*GP*GP*G)-3') Authors: Lenarcic Zivkovic, M, Plavec, J. Deposit date: 2020-07-13 Release date: 2021-05-26 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of a DNA G-Quadruplex Related to Osteoporosis with a G-A Bulge Forming a Pseudo-loop . Molecules, 25, 2020
2F8U	G-quadruplex structure formed in human Bcl-2 promoter, hybrid form Descriptor: 5'-D(*GP*GP*GP*CP*GP*CP*GP*GP*GP*AP*GP*GP*AP*AP*TP*TP*GP*GP*GP*CP*GP*GP*G)-3' Authors: Dai, J, Chen, D, Carver, M, Yang, D. Deposit date: 2005-12-03 Release date: 2006-11-07 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Res., 34, 2006
8R6D	A quadruplex-duplex hybrid with a three-layered hybrid-2 G-quadruplex topology Descriptor: DNA (31-MER) Authors: Vianney, Y.M, Weisz, K. Deposit date: 2023-11-22 Release date: 2024-03-06 Last modified: 2024-07-10 Method: SOLUTION NMR Cite: Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions. Adv Sci, 11, 2024
8R6G	A quadruplex-duplex hybrid with a three-layered chair G-quadruplex topology Descriptor: DNA (33-MER) Authors: Vianney, Y.M, Weisz, K. Deposit date: 2023-11-22 Release date: 2024-03-13 Last modified: 2024-07-10 Method: SOLUTION NMR Cite: Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions. Adv Sci, 11, 2024
8R6H	A quadruplex-duplex hybrid with a three-layered hybrid-2 G-quadruplex topology complexed with Phen-DC3 Descriptor: DNA (34-MER), N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide Authors: Vianney, Y.M, Weisz, K. Deposit date: 2023-11-22 Release date: 2024-03-06 Last modified: 2024-07-10 Method: SOLUTION NMR Cite: Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions. Adv Sci, 11, 2024
6LNZ	NMR solution structure of VEGF G-quadruplex bound a non-planar cyclometalated-carbene platinum(II) complex Descriptor: DNA (5'-D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), cyclometalated-carbene platinum(II) complex Authors: Liu, W, Zhu, B.Z, Mao, Z.W. Deposit date: 2020-01-02 Release date: 2021-01-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Selectivity and Targeting of G-Quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew.Chem.Int.Ed.Engl., 60, 2021
7OAR	Crystal structure of helicase Pif1 from Thermus oshimai in complex with parallel G-quadruplex Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (28-MER), MAGNESIUM ION, ... Authors: Dai, Y.X, Liu, N.N, Guo, H.L, Chen, W.F, Rety, S, Xi, X.G. Deposit date: 2021-04-20 Release date: 2022-03-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Structural mechanism underpinning Thermus oshimai Pif1-mediated G-quadruplex unfolding. Embo Rep., 23, 2022
8ABD	Solution structure of Phen-DC3 intercalating into a quadruplex-duplex hybrid Descriptor: DNA (36-MER), N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide Authors: Vianney, Y.M, Weisz, K. Deposit date: 2022-07-04 Release date: 2022-11-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: High-affinity binding at quadruplex-duplex junctions: rather the rule than the exception. Nucleic Acids Res., 50, 2022
8ABN	Solution structure of a phenyl-indoloquinoline intercalating into a quadruplex-duplex hybrid Descriptor: DNA (27-MER), diethyl-[3-[[4-(4,5,9-trimethyl-10H-indolo[3,2-b]quinolin-5-ium-11-yl)phenyl]carbonylamino]propyl]azanium Authors: Vianney, Y.M, Weisz, K. Deposit date: 2022-07-04 Release date: 2022-11-16 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: High-affinity binding at quadruplex-duplex junctions: rather the rule than the exception. Nucleic Acids Res., 50, 2022
8PSI	G-quadruplex with a 1-nt V-shaped loop from a G-rich sequence with five G-runs Descriptor: DNA (5'-D(*GP*GP*GP*TP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*GP*CP*AP*GP*GP*GP*T)-3') Authors: Vianney, Y.M, Schroeder, N, Jana, J, Weisz, K. Deposit date: 2023-07-13 Release date: 2023-09-27 Last modified: 2023-10-18 Method: SOLUTION NMR Cite: Showcasing Different G-Quadruplex Folds of a G-Rich Sequence: Between Rule-Based Prediction and Butterfly Effect. J.Am.Chem.Soc., 145, 2023
5W77	Solution structure of the MYC G-quadruplex bound to small molecule DC-34 Descriptor: 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide, DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION Authors: Chen, X, Walters, K.J. Deposit date: 2017-06-19 Release date: 2018-10-24 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun, 9, 2018
7JKU	Crystal structure of a four-tetrad, parallel, and K+ stabilized Tetrahymena thermophila telomeric G-quadruplex Descriptor: 26-mer DNA, POTASSIUM ION Authors: Yatsunyk, L.A, McCarthy, S.E, Beseiso, D, Gallagher, E.P, Chen, E.V, Miao, J. Deposit date: 2020-07-28 Release date: 2021-07-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.97 Å) Cite: The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes. Nucleic Acids Res., 50, 2022
6K3Y	G-quadruplex complex with cyclic dinucleotide 3'-3' cGAMP Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, DNA (5'-D(*TP*TP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') Authors: Winnerdy, F.R, Heddi, B, Phan, A.T. Deposit date: 2019-05-22 Release date: 2020-01-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides. J.Am.Chem.Soc., 141, 2019
6JCD	G-quadruplex peripheral knot Descriptor: 24-mer DNA Authors: Winnerdy, F.R, Truong, T.H.A, Phan, A.T. Deposit date: 2019-01-28 Release date: 2019-08-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: An Unprecedented Knot-like G-Quadruplex Peripheral Motif. Angew.Chem.Int.Ed.Engl., 58, 2019
7CV4	Quadruplex-duplex hybrid structure in the PIM1 gene, Form 2 Descriptor: DNA (26-MER) Authors: Winnerdy, F.R, Tan, D.T.J, Lim, K.W, Phan, A.T. Deposit date: 2020-08-25 Release date: 2020-10-07 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Coexistence of two quadruplex-duplex hybrids in the PIM1 gene. Nucleic Acids Res., 48, 2020

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