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6Y8M	Fragment bikinin bound to Interleukin 1 beta Descriptor: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-05 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment bikinin bound to Interleukin 1 beta To Be Published
2WRY	Crystal structure of chicken cytokine interleukin 1 beta Descriptor: INTERLEUKIN-1BETA Authors: Lu, W.S, Cheng, C.S, Lyu, P.C, Lee, L.H, Wang, W.C, Yin, H.S. Deposit date: 2009-09-03 Release date: 2010-09-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural and Functional Comparison of Cytokine Interleukin-1 Beta from Chicken and Human. Mol.Immunol., 48, 2011
6HPI	NMR structure of the pro-inflammatory cytokine interleukin-36alpha Descriptor: Interleukin-36 alpha Authors: Ohlenschlaeger, O, Imhof, D. Deposit date: 2018-09-21 Release date: 2019-10-02 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Biomol NMR Assign, 10, 2016
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule Descriptor: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... Authors: Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. Deposit date: 2012-10-12 Release date: 2013-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
4I1B	FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Raag, R, Svensson, L.A, Masui, Y, Hirai, Y. Deposit date: 1990-03-27 Release date: 1990-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins, 12, 1992
3NJ5	Crystal structure of chicken IL-1 hydrophobic cavity mutant 157 Descriptor: IL-1 beta Authors: Yin, H.S, Chen, Y.W. Deposit date: 2010-06-17 Release date: 2011-06-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Structural and functional comparison of cytokine interleukin-1 beta from chicken and human Mol.Immunol., 48, 2011
7CHY	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26 Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26, light chain of antibody binding fragment of IgG26 Authors: Lee, C.C, Wang, A.H.J, Kuo, W.C. Deposit date: 2020-07-06 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
4P0K	Crystal Structure of Double Loop-Swapped Interleukin-36Ra Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
7CHZ	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26A, light chain of antibody binding fragment of IgG26A Authors: Lee, C.C, Wang, A.H.J, Kuo, W.C. Deposit date: 2020-07-06 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
4P0J	Crystal Structure of Loop-Swapped Interleukin-36Ra Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.298 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4P0L	Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4IZE	Crystal Structure of IL-36gamma Descriptor: Interleukin-36 gamma Authors: Guenther, S, Sundberg, E.J. Deposit date: 2013-01-29 Release date: 2014-06-25 Last modified: 2014-07-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014
3POK	Interleukin-1-beta LBT L3 Mutant Descriptor: Interleukin-1 beta Authors: Barthelmes, K, Reynolds, A.M, Peisach, E, Jonker, H.R.A, DeNunzio, N.J, Allen, K.N, Imperiali, B, Schwalbe, H. Deposit date: 2010-11-22 Release date: 2011-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
3WO2	Crystal structure of human interleukin-18 Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION Authors: Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. Deposit date: 2013-12-19 Release date: 2014-12-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.33 Å) Cite: The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
3WO3	Crystal structure of IL-18 in complex with IL-18 receptor alpha Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. Deposit date: 2013-12-19 Release date: 2014-12-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.1 Å) Cite: The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
41BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 8 REPLACED BY ALA (C8A) Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. Deposit date: 1992-02-03 Release date: 1992-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite:
8RZB	IL-1beta in complex with covalent DEL hit Descriptor: 8-[4-methyl-3-(trifluoromethyl)phenyl]-2-[[(7S)-7-(2-morpholin-4-ylethylcarbamoyl)-4-(phenylsulfonyl)-1,4-diazepan-1-yl]carbonyl]imidazo[1,2-a]pyridine-6-carboxylic acid, Interleukin-1 beta Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-12 Release date: 2024-05-22 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.836 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8RYK	IL-1beta in complex with macrocyclic peptide hit Descriptor: Interleukin-1 beta, Macrocyclic peptide Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-09 Release date: 2024-05-22 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8RYS	Human IL-1beta, unliganded Descriptor: Interleukin-1 beta, SULFATE ION Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2024-02-09 Release date: 2024-03-06 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
4G6J	Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.03 Å) Cite: One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425, 2013
1S0L	Interleukin 1 beta mutant F42W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L.D. Deposit date: 2003-12-31 Release date: 2004-03-30 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1T4Q	Interleukin 1 beta F101W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-04-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Capsar, D.L. Deposit date: 2004-06-30 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TOO	Interleukin 1B Mutant F146W Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-14 Release date: 2004-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TP0	Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan. Descriptor: Interleukin-1 beta Authors: Adamek, D.H, Guerrero, L, Caspar, D.L. Deposit date: 2004-06-15 Release date: 2005-02-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005

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