PDB: 221716 resultsInfo pagesStatus searchChemie searchBIRD

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8SP6	COMPLEX STRUCTURE OF CDYL2 WITH AN ANTAGONIST Descriptor: (1s,4s)-bicyclo[2.2.1]heptane, (5R0)FAL(MLZ)(5R5), Chromodomain Y-like protein 2, ... Authors: Song, X, Beldar, S, Dong, A, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2023-05-02 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.45 Å) Cite: COMPLEX STRUCTURE OF CDYL2 WITH AN ANTAGONIST To be published
8SP5	LINE-1 retrotransposon endonuclease domain complex with Mn2+ Descriptor: LINE-1 retrotransposon endonuclease, MANGANESE (II) ION, SULFATE ION Authors: D'Ordine, A.M, Jogl, G, Sedivy, J.M. Deposit date: 2023-05-02 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun, 15, 2024
8SP3	Asymmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid Descriptor: MAGNESIUM ION, TIR-APAZ, guide RNA, ... Authors: Shen, Z.F, Yang, X.Y, Fu, T.M. Deposit date: 2023-05-01 Release date: 2023-08-23 Last modified: 2023-09-20 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
8SP2	Crystal structure of metformin hydrolase (MfmAB) from Pseudomonas mendocina sp. MET-2 apo form Descriptor: NICKEL (II) ION, metformin hydrolase subunit A, metformin hydrolase subunit B Authors: Tassoulas, L.J, Rankin, J.A, Elias, M.H, Wackett, L.P. Deposit date: 2023-05-01 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc.Natl.Acad.Sci.USA, 121, 2024
8SP1	Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGIAAGTGGG) Descriptor: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... Authors: Terrell, J.R, Poon, G.M.K. Deposit date: 2023-05-01 Release date: 2023-11-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure, 32, 2024
8SP0	Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid Descriptor: MAGNESIUM ION, TIR-APAZ, guide RNA, ... Authors: Shen, Z.F, Yang, X.Y, Fu, T.M. Deposit date: 2023-05-01 Release date: 2023-08-23 Last modified: 2023-09-20 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
8SOY	Cryo-EM structure of Enoyl-CoA hydratase from Mycobacterium smegmatis Descriptor: Enoyl-CoA hydratase EchA21 Authors: Shek, R, Quispe, J, Staker, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-04-30 Release date: 2023-05-10 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Cryo-EM structure of Enoyl-CoA hydratase from Mycobacterium smegmatis To Be Published
8SOV	Proteinase K Multiconformer Model at 353K Descriptor: ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-30 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.291 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOU	Proteinase K Multiconformer Model at 363K Descriptor: ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-30 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOT	Structure of the PPIase domain of borrelial BB0108 Descriptor: Basic membrane protein, GLYCEROL Authors: Shakya, A.K, Herzberg, O. Deposit date: 2023-04-30 Release date: 2023-10-11 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.99 Å) Cite: A unique borrelial protein facilitates microbial immune evasion. Mbio, 14, 2023
8SOS	Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d, Beta-2-microglobulin, ... Authors: Shahine, A, Rossjohn, J. Deposit date: 2023-04-29 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions. J Immunother Cancer, 11, 2023
8SOR	Structure of human PI3KC3-C1 complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Beclin 1-associated autophagy-related key regulator, Beclin-1, ... Authors: Chen, M, Hurley, J.H. Deposit date: 2023-04-29 Release date: 2023-06-21 Last modified: 2023-06-28 Method: ELECTRON MICROSCOPY (3.96 Å) Cite: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
8SOQ	S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with authentic substrate NaAD Descriptor: MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase Authors: Chatterjee, S, Rankin, J.A, Hu, J, Hausinger, R.P. Deposit date: 2023-04-29 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the LarB-Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis. Biochemistry, 62, 2023
8SON	Crystal structure of macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide Descriptor: (2R)-3-[(2-chlorophenyl)amino]-2-cyano-3-thioxo-N-[3-(trifluoromethyl)phenyl]propanamide, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2023-04-28 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of the macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide To Be Published
8SOK	Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: Cai, S.W. Deposit date: 2023-04-28 Release date: 2023-06-07 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres. Biorxiv, 2023
8SOJ	Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: Cai, S.W. Deposit date: 2023-04-28 Release date: 2023-06-07 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres. Biorxiv, 2023
8SOI	Structure of human ULK1 complex core (2:1:1 stoichiometry) Descriptor: Autophagy-related protein 13, RB1-inducible coiled-coil protein 1, Serine/threonine-protein kinase ULK1 Authors: Chen, M, Hurley, J.H. Deposit date: 2023-04-28 Release date: 2023-06-21 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
8SOG	Proteinase K Multiconformer Model at 313K Descriptor: CALCIUM ION, Proteinase K, SULFATE ION Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-28 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOE	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOD	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOC	Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOB	Phosphoinositide phosphate 3 kinase gamma bound with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOA	Phosphoinositide phosphate 3 kinase gamma bound with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SO9	Phosphoinositide phosphate 3 kinase gamma Descriptor: Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SO5	Crystal structure of the engineered quorum quenching acylase MacQ variant M1 - acylated form Descriptor: DECANOIC ACID, Protein related to penicillin acylase Authors: Sompiyachoke, K, Elias, M. Deposit date: 2023-04-28 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Engineering quorum quenching acylases with improved kinetic and biochemical properties. Protein Sci., 33, 2024

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