PDB: 5434 resultsInfo pagesStatus searchChemie searchBIRD

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2LDU	Solution NMR Structure of Heat shock factor protein 1 DNA binding domain from homo sapiens, Northeast Structural Genomics Consortium Target HR3023C Descriptor: Heat shock factor protein 1 Authors: Liu, G, Xiao, R, Ciccosanti, C, Janjua, H, Acton, T.B, Lee, H, Wang, H.B, Huang, Y.B, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) Deposit date: 2011-06-01 Release date: 2011-07-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Northeast Structural Genomics Consortium Target HR3023C To be Published
2LF8	Intramolecular regulation of the ETS Domain within ETV6 sequence R335 to R458 Descriptor: Transcription factor ETV6 Authors: Coyne III, H, Green, S.M, Graves, B.J, Mcintosh, L.P. Deposit date: 2011-06-28 Release date: 2012-05-23 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain. J.Mol.Biol., 421, 2012
2LVM	Solution structure of human 53BP1 tandem Tudor domains in complex with a histone H4K20me2 peptide Descriptor: Histone H4, Tumor suppressor p53-binding protein 1 Authors: Cui, G, Botuyan, M, Mer, G. Deposit date: 2012-07-07 Release date: 2012-12-12 Last modified: 2013-04-03 Method: SOLUTION NMR Cite: Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat.Struct.Mol.Biol., 20, 2013
3QQ8	Crystal structure of p97-N in complex with FAF1-UBX Descriptor: CHLORIDE ION, FAS-associated factor 1, Transitional endoplasmic reticulum ATPase Authors: Haenzelmann, P, Schindelin, H. Deposit date: 2011-02-15 Release date: 2011-06-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Hierarchical Binding of Cofactors to the AAA ATPase p97. Structure, 19, 2011
7V6Q	Crystal structure of sNASP-ASF1A-H3.1-H4 complex Descriptor: GLYCEROL, Histone H3.1, Histone H4, ... Authors: Liu, C.P, Xu, R.M. Deposit date: 2021-08-20 Release date: 2021-12-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev., 35, 2021
7VDC	3.28 A structure of the rabbit muscle aldolase Descriptor: Fructose-bisphosphate aldolase A Authors: Fan, H.C, Zhang, Y, Sun, F. Deposit date: 2021-09-06 Release date: 2021-12-29 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI. Nat Commun, 12, 2021
7VBM	The mouse nucleosome structure containing H3mm18 aided by PL2-6 scFv Descriptor: DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... Authors: Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. Deposit date: 2021-08-31 Release date: 2022-01-19 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant. Nucleic Acids Res., 50, 2022
3R27	Crystal structure of the first RRM domain of heterogeneous nuclear ribonucleoprotein L (HnRNP L) Descriptor: GLYCEROL, Heterogeneous nuclear ribonucleoprotein L Authors: Zhang, W, Liu, Y, Zeng, F, Niu, L, Teng, M, Li, X. Deposit date: 2011-03-14 Release date: 2011-09-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Crystal structure of the first RRM domain of heterogeneous nuclear ribonucleoprotein L (HnRNP L) To be Published
7VCU	Human p97 double hexamer conformer I with D1-ATPgammaS and D2-ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. Deposit date: 2021-09-04 Release date: 2022-03-02 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
7VCT	Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. Deposit date: 2021-09-04 Release date: 2022-03-02 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
7VCX	Human p97 single hexamer conformer II with ATPgammaS bound Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. Deposit date: 2021-09-04 Release date: 2022-03-02 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
3RAN	CANINE GDP-RAN Q69L MUTANT Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (GTP-BINDING NUCLEAR PROTEIN RAN) Authors: Stewart, M, Kent, H.M, Mccoy, A.J. Deposit date: 1998-10-19 Release date: 1998-12-02 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J.Mol.Biol., 284, 1998
7VCS	Human p97 double hexamer conformer II with ATPgammaS bound Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. Deposit date: 2021-09-03 Release date: 2022-03-02 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
7VCV	Human p97 single hexamer conformer I with ATPgammaS bound Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. Deposit date: 2021-09-04 Release date: 2022-03-02 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
3RDD	Human Cyclophilin A Complexed with an Inhibitor Descriptor: Peptidyl-prolyl cis-trans isomerase A, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate Authors: Colliandre, L, Ahmed-Belkacem, H, Bessin, Y, Pawlotsky, J.M, Guichou, J.F. Deposit date: 2011-04-01 Release date: 2012-03-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
7VQS	Crystal structure of LSD1 in complex with compound 4 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
7VQT	Crystal structure of LSD1 in complex with compound 5 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-4-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
7VQU	Crystal structure of LSD1 in complex with compound S1427 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
3THB	Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor Descriptor: 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thi one, Serine/threonine-protein kinase PLK1, ZINC ION Authors: Sintchak, M.D. Deposit date: 2011-08-18 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J.Med.Chem., 55, 2012
7VIJ	Crystal structure of USP7-HUBL domain Descriptor: Ubiquitin carboxyl-terminal hydrolase 7 Authors: Feng, N, Zeng, K.W. Deposit date: 2021-09-27 Release date: 2022-08-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv, 8, 2022
7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex Descriptor: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... Authors: Wang, D, Xu, J, Liu, Q, Xiang, Y. Deposit date: 2021-08-21 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7V9B	Crystal Structure of 14-3-3 epsilon with FOXO3a peptide Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ... Authors: Mathivanan, S, Kamariah, N. Deposit date: 2021-08-24 Release date: 2022-08-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins. Acs Omega, 7, 2022
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation Descriptor: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 Authors: Wang, D, Xu, J, Liu, Q, Xiang, Y. Deposit date: 2021-08-21 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
3SZM	STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE Descriptor: Histone H2A.x, Microcephalin Authors: Singh, N, Thompson, J.R, Mer, G. Deposit date: 2011-07-19 Release date: 2011-11-30 Last modified: 2012-09-19 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc.Natl.Acad.Sci.USA, 109, 2012
3SVF	Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand Descriptor: (4S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(2-hydroxyethoxy)-3-methyl-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 Authors: Filippakopoulos, P, Picaud, S, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2011-07-12 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.975 Å) Cite: Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand TO BE PUBLISHED

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