3SVF

Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand

Summary for 3SVF

• Entry DOI: 10.2210/pdb3svf/pdb
• Related: 3SVG 3SVH
• Descriptor: Bromodomain-containing protein 4, (4S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(2-hydroxyethoxy)-3-methyl-3,4-dihydroquinazolin-2(1H)-one (3 entities in total)
• Functional Keywords: bromodomain, structural genomics, structural genomics consortium, sgc, unknown function
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): O60885
• Total number of polymer chains: 1
• Total formula weight: 15416.72

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-07-12, release date: 2011-08-10, Last modification date: 2023-09-13)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.; Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.975 Å)