7VQT

Crystal structure of LSD1 in complex with compound 5

Summary for 7VQT

Entry DOI	10.2210/pdb7vqt/pdb
Descriptor	Lysine-specific histone demethylase 1A, GLYCEROL, L(+)-TARTARIC ACID, ... (5 entities in total)
Functional Keywords	demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	75932.31
Authors	Niwa, H.,Koda, Y.,Sato, S.,Yamamoto, H.,Koyama, H.,Umehara, T. (deposition date: 2021-10-20, release date: 2022-06-01, Last modification date: 2023-11-29)
Primary citation	Koda, Y.,Sato, S.,Yamamoto, H.,Niwa, H.,Watanabe, H.,Watanabe, C.,Sato, T.,Nakamura, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Fukami, T.,Koyama, H.,Umehara, T. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13:848-854, 2022 Cited by PubMed: 35586426 DOI: 10.1021/acsmedchemlett.2c00120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation