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6T6C
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Complex with chitin oligomer of C-type lysozyme from the upper gastrointestinal tract of Opisthocomus hoatzin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C
Authors:Taylor, E.J, Skjot, M, Skov, L.K, Klausen, M, De Maria, L, Gippert, G.P, Turkenburg, J.P, Davies, G.J, Wilson, K.S.
Deposit date:2019-10-18
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The C-Type Lysozyme from the upper Gastrointestinal Tract of Opisthocomus hoatzin, the Stinkbird.
Int J Mol Sci, 20, 2019
8GKV
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BU of 8gkv by Molmil
Crystal structure of anti-adaptor IraP that regulates RpoS proteolysis
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Shaw, G.X, Gan, J, Suburaman, P, Battesti, A, Zhou, Y.N, Wickner, S, Gottesman, S, Ji, X.
Deposit date:2023-03-20
Release date:2024-03-27
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Structural and functional study of anti-adaptor IraP-mediated regulation of RpoS proteolysis
to be published
7KHK
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Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the DFG-in state
Descriptor: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
7KHJ
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BU of 7khj by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX8512 in the DFG-in state
Descriptor: 2-phenyl-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
7KHG
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BU of 7khg by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397
Descriptor: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
4TWE
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BU of 4twe by Molmil
Structure of ligand-free N-acetylated-alpha-linked-acidic-dipeptidase like protein (NAALADaseL)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Barinka, C, Lubkowski, J, Sacha, P, Konvalinka, J.
Deposit date:2014-06-30
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and biochemical characterization of a novel aminopeptidase from human intestine.
J.Biol.Chem., 290, 2015
6GQK
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Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 23)
Descriptor: Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
Authors:Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
2V90
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BU of 2v90 by Molmil
Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)
Descriptor: PDZ DOMAIN-CONTAINING PROTEIN 3, SULFATE ION
Authors:Uppenberg, J, Gileadi, C, Phillips, C, Elkins, J, Bunkoczi, G, Cooper, C, Pike, A.C.W, Salah, E, Ugochukwu, E, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Weigelt, J, Doyle, D.A.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the 3Rd Pdz Domain of Intestine- and Kidney-Enriched Pdz Domain Ikepp (Pdzd3)
To be Published
1PE3
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BU of 1pe3 by Molmil
Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)
Descriptor: Trefoil factor 3
Authors:Muskett, F.W, May, F.E, Westley, B.R, Feeney, J.
Deposit date:2003-05-21
Release date:2004-03-09
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins.
Biochemistry, 42, 2003
3AKN
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BU of 3akn by Molmil
X-ray structure of iFABP from human and rat with bound fluorescent fatty acid analogue
Descriptor: 11-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)undecanoic acid, Fatty acid-binding protein, intestinal
Authors:Wielens, J, Laguerre, A.J.K, Parker, M.W, Scanlon, M.J.
Deposit date:2010-07-14
Release date:2011-07-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of human and rat intestinal fatty acid binding protein in complex with 11-(Dansylamino)undecanoic acid
To be Published
1T79
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BU of 1t79 by Molmil
Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLW motif
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, FxxLW motif peptide
Authors:Hur, E, Pfaff, S.J, Payne, E.S, Gron, H, Buehrer, B.M, Fletterick, R.J.
Deposit date:2004-05-08
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recognition and accommodation at the androgen receptor coactivator binding interface.
Plos Biol., 2, 2004
1T7F
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BU of 1t7f by Molmil
Crystal structure of the androgen receptor ligand binding domain in complex with a LxxLL motif
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, LxxLL motif peptide
Authors:Hur, E, Pfaff, S.J, Payne, E.S, Gron, H, Buehrer, B.M, Fletterick, R.J.
Deposit date:2004-05-10
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Recognition and accommodation at the androgen receptor coactivator binding interface.
Plos Biol., 2, 2004
7A1R
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BU of 7a1r by Molmil
Crystal structure of the C2B domain of Trypanosoma brucei extended synaptotagmin (E-Syt)
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Dong, G.
Deposit date:2020-08-13
Release date:2021-06-02
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei .
Iscience, 24, 2021
1ETN
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BU of 1etn by Molmil
MOLECULAR STRUCTURE OF THE TOXIC DOMAIN OF HEAT-STABLE ENTEROTOXIN PRODUCED BY A PATHOGENIC STRAIN OF ESCHERICHIA COLI
Descriptor: 5-BETA-MERCAPTOPROPIONATE HEAT-STABLE ENTEROTOXIN
Authors:Sato, T, Shimonishi, Y.
Deposit date:1994-03-15
Release date:1996-01-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Molecular structure of the toxin domain of heat-stable enterotoxin produced by a pathogenic strain of Escherichia coli. A putative binding site for a binding protein on rat intestinal epithelial cell membranes.
J.Biol.Chem., 266, 1991
3DHE
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BU of 3dhe by Molmil
ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DEHYDROEPIANDROSTERONE
Descriptor: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE
Authors:Han, Q, Campbell, R.L, Gangloff, A, Lin, S.X.
Deposit date:1998-03-25
Release date:1999-09-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.
J.Biol.Chem., 275, 2000
1T65
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BU of 1t65 by Molmil
Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 2
Authors:Estebanez-Perpina, E, Moore, J.M.R, Mar, E, Nguyen, P, Delgado-Rodrigues, E, Baxter, J.D, Webb, P, Fletterick, R.J, Guy, R.K.
Deposit date:2004-05-05
Release date:2005-01-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
3L3Z
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BU of 3l3z by Molmil
Crystal structure of DHT-bound androgen receptor in complex with the third motif of steroid receptor coactivator 3
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 3
Authors:Zhou, X.E, Suino-Powell, K.M, Li, J, He, A, MacKeigan, J.P, Melcher, K, Yong, E.-L, Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
2ACY
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BU of 2acy by Molmil
ACYL-PHOSPHATASE (COMMON TYPE) FROM BOVINE TESTIS
Descriptor: ACYLPHOSPHATASE, CHLORIDE ION, SULFATE ION
Authors:Thunnissen, M.M.G.M, Nordlund, P.
Deposit date:1996-11-08
Release date:1997-11-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of common type acylphosphatase from bovine testis.
Structure, 5, 1997
3L3X
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BU of 3l3x by Molmil
Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 3
Authors:Zhou, X.E, Suino-Powell, K.M, Li, J, He, A, MacKeigan, J.P, Melcher, K, Yong, E.-L, Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
1KEY
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BU of 1key by Molmil
Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)
Descriptor: translin
Authors:Pascal, J.M, Hart, P.J, Hecht, N.B, Robertus, J.D.
Deposit date:2001-11-19
Release date:2002-07-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of TB-RBP, a Novel RNA-binding and Regulating Protein
J.Mol.Biol., 319, 2002
6TRO
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BU of 6tro by Molmil
Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV
Descriptor: Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239), MHC class I antigen, ...
Authors:Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S.
Deposit date:2019-12-19
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
J.Biol.Chem., 295, 2020
6TRN
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BU of 6trn by Molmil
Crystal structure of HLA A2*01-AVYDGREHTV
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239) variant, ...
Authors:Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S.
Deposit date:2019-12-19
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
J.Biol.Chem., 295, 2020
6H16
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BU of 6h16 by Molmil
Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor-related protein 6, ...
Authors:Gros, P, van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6H15
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Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Gros, P, van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6YMF
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BU of 6ymf by Molmil
Crystal structure of serine hydroxymethyltransferase from Aphanothece halophytica in the PLP-Serine external aldimine state
Descriptor: GLYCEROL, PENTAETHYLENE GLYCOL, Serine hydroxymethyltransferase, ...
Authors:Ruszkowski, M, Sekula, B, Nogues, I, Tramonti, A, Angelaccio, S, Contestabile, R.
Deposit date:2020-04-08
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium Aphanothece halophytica provide a rationale for salt tolerance.
Int.J.Biol.Macromol., 159, 2020

221716

数据于2024-06-26公开中

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